Magnetic resonance imaging surrogates of molecular subgroups in atypical teratoid/rhabdoid tumor

Neuro-oncology
Johannes NowakMonika Warmuth-Metz

Abstract

Recently, 3 molecular subgroups of atypical teratoid/rhabdoid tumor (ATRT) were identified, but little is known of their clinical and magnetic resonance imaging (MRI) characteristics. A total of 43 patients with known molecular subgroup status (ATRT-sonic hedgehog [SHH], n = 17; ATRT-tyrosine [TYR], n = 16; ATRT-myelocytomatosis oncogene [MYC], n = 10) were retrieved from the EU-RHAB Registry and analyzed for clinical and MRI features. On MRI review, differences in preferential tumor location were confirmed, with ATRT-TYR being predominantly located infratentorially (P < 0.05). Peritumoral edema was more pronounced in ATRT-MYC compared with ATRT-SHH (P < 0.05) and ATRT-TYR (P < 0.05). Conversely, peripheral tumor cysts were found more frequently in ATRT-SHH (71%) and ATRT-TYR (94%) compared with ATRT-MYC (40%, P < 0.05). Contrast enhancement was absent in 29% of ATRT-SHH (0% of ATRT-TYR; 10% of ATRT-MYC; P < 0.05), and there was a trend toward strong contrast enhancement in ATRT-TYR and ATRT-MYC. We found the characteristic (bandlike) enhancement in 28% of ATRT as well as restricted diffusion in the majority of tumors. A midline/off-midline location in the posterior fossa was also not subgroup specific. Visible meningeal spread...Continue Reading

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Citations

May 10, 2020·AJNR. American Journal of Neuroradiology·C JaimesT Y Poussaint
Jun 17, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Karen Buch
Oct 7, 2020·Journal of Neuro-oncology·Cody L NesvickDavid J Daniels
Mar 6, 2021·AJNR. American Journal of Neuroradiology·C A P F AlvesF D'Arco

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