Magnetic resonance spectroscopic imaging in temporal lobe epilepsy: neuronal dysfunction or cell loss?

Archives of Neurology
R KuznieckyR Knowlton

Abstract

Magnetic resonance spectroscopy (MRS) has demonstrated consistent metabolic abnormalities in temporal lobe epilepsy. The reason for decreases in N-acetylated compounds are thought to be related to neuronal hippocampal cell loss as observed in hippocampal sclerosis. However, mounting evidence suggest that the N-acetylated compound decreases may be functional and reversible. To establish whether the metabolic changes measured by MRS correlate to hippocampal cell loss in temporal lobe epilepsy. We prospectively performed quantitative hippocampal MR imaging volumetry and MRS imaging in 33 patients with intractable mesial temporal lobe epilepsy who were undergoing surgery. A neuronal-glial ratio of cornu ammonis and fascia dentata was obtained and correlated while validating the pathologic analysis by comparisons with specimens of age-matched autopsy control-case hippocampus (n = 14). The neuronal-glial ratio of the patient group was statistically significantly lower than in the control group for the cornu ammonis region (P<.001). Correlations of hippocampal volumes with cornu ammonis and neuronal-glial ratios revealed a significant interdependence (P<.01). However, correlations of the resected hippocampal creatine-N-acetylated comp...Continue Reading

Citations

May 3, 2014·Annals of Indian Academy of Neurology·Zulfi Haneef, David K Chen
Oct 19, 2011·Biomarkers in Medicine·William A Gomes, Shlomo Shinnar
Jan 19, 2013·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Hasan AydinBaki Hekimoglu
Oct 27, 2009·Neurochemical Research·Zsolt KovácsKatalin A Kékesi
Feb 18, 2010·Future Neurology·Hoby Hetherington
Jan 12, 2007·Epilepsy & Behavior : E&B·Elizabeth J RichardsonMichael Seidenberg
Jul 30, 2004·Epilepsia·Hoby P HetheringtonDennis D Spencer
Mar 11, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E DüzelH J Heinze
Nov 19, 2003·The European Journal of Neuroscience·Stefan VielhaberWolfram S Kunz
May 26, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T HammenH Stefan
Feb 14, 2007·Epilepsia·Regula S BriellmannGraeme D Jackson
Mar 21, 2007·Magnetic Resonance Imaging·Sergio UribePablo Irarrázaval
May 15, 2013·Neurochemistry International·Andre Obenaus
Aug 25, 2004·Neuroimaging Clinics of North America·Ruben Kuzniecky
Feb 24, 2009·British Journal of Neurosurgery·Mary A McLean, Justin J Cross
Mar 8, 2017·Epilepsia·Wolfgang MuhlhoferRobert Knowlton
Dec 14, 2004·Journal of Neurology·András SzentkutiEmrah Düzel
Mar 4, 2006·Epilepsy Research·Pedro M Gonçalves PereiraPedro Rosado
Apr 25, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Olav B SmelandKarin Borges
Mar 20, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tesfaye W Tefera, Karin Borges
Mar 17, 2004·Current Opinion in Neurology·Robert C Knowlton
Oct 29, 2002·Annals of Neurology·Ognen A C PetroffDennis D Spencer
Apr 25, 2007·NMR in Biomedicine·Ji-Kyung ChoiBruce G Jenkins
Feb 25, 2005·Brain : a Journal of Neurology·Anne WilliamsonHoby Hetherington
Nov 30, 2007·Nature Clinical Practice. Neurology·Ruben Kuzniecky, Orrin Devinsky
Jul 1, 2006·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Peter Widdess-WalshImad Najm
Oct 23, 2009·Epilepsia·Bruno A G CamposFernando Cendes
Dec 31, 2010·Korean journal of pediatrics·Da Eun Jung, Joon-Soo Lee
Mar 8, 2006·NMR in Biomedicine·Franz RiedererWolfgang Serles
Feb 1, 2003·Epilepsia·Staffan LundbergRaili Raininko
Jun 4, 2010·Expert Review of Neurotherapeutics·Mark Richardson
Sep 14, 2012·Epilepsia·Kristina Malmgren, Maria Thom
May 16, 2019·Journal of the International Neuropsychological Society : JINS·Haya F Al-JoudiJason Brandt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.