Magnetic resonance spectroscopy detection of high lipid levels in intraaxial tumors without central necrosis: a characteristic of malignant lymphoma

Journal of Neurosurgery
Fumiyuki YamasakiKaoru Kurisu

Abstract

The differentiation of malignant lymphomas from gliomas or malignant gliomas by conventional MRI can be difficult. The authors studied Gd-enhanced MR images to obtain a differential diagnosis between malignant lymphomas and gliomas without central necrosis or cystic changes and investigated the diagnostic value of single-voxel proton MR spectroscopy ((1)H-MRS) using different parameters, including lipid levels. This was a retrospective study of patients with primary malignant CNS lymphoma (n = 17) and glioma (n = 122 [Grades I, II, III, and IV in 10, 30, 33, and 49 patients, respectively]) who were treated between 2007 and 2013. The authors focused on 15 patients with homogeneously enhanced primary malignant CNS lymphomas and 7 homogeneously enhanced gliomas. Images of all the included tumors were acquired with (1)H-MRS at 3 T, and the diagnoses were histologically confirmed. Using a short echo time (1)H-MRS, large lipid peaks were observed in all 17 patients with a malignant lymphoma, in 39 patients (79.6%) with a Grade IV glioma, and in 10 patients (30.3%) with a Grade III glioma. A focus on homogeneously enhanced tumors revealed large lipid peaks in 15 malignant lymphomas that were free of central necrosis on Gd-enhanced T1-...Continue Reading

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Citations

Jun 6, 2016·Journal of Neuroradiology. Journal De Neuroradiologie·Marianne TheillacFrançois Cotton
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·O Rapalino, E M Ratai
Nov 30, 2016·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·H MalikovaZ Vojtech
Oct 7, 2017·The Journal of International Medical Research·Huafeng WangJie Jin
May 28, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Nijiati KudulaitiJinsong Wu
Dec 12, 2019·NMR in Biomedicine·Valeria RighiMarina Cocchi
Sep 16, 2015·Current Opinion in Oncology·Andreas F HottingerKhê Hoang-Xuan
Jan 25, 2021·La Radiologia medica·Matteo PaolettiAnna Pichiecchio
Jul 3, 2021·Pharmaceutics·Samantha Gokhale, Ping Xie

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Methods Mentioned

BETA
biopsy
flow-cytometry

Software Mentioned

StatView
FuncTool
LCModel
SAS

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