PMID: 7546001May 1, 1995Paper

Magnetic resonance spectroscopy in childhood AIDS encephalopathy

Pediatric Neurology
S G PavlakisR A Hyman

Abstract

Twenty-five children with acquired immunodeficiency syndrome (AIDS) underwent cranial magnetic resonance imaging and proton magnetic resonance spectroscopy. Patients were divided into 2 groups based on clinical parameters: encephalopathy and nonencephalopathy. N-acetyl aspartate/creatine ratios were compared between the 2 groups and to control data. Spectra were obtained for 2 volumes of interest: the basal ganglia region and the white matter. The mean basal ganglia region ratio for the AIDS encephalopathy patients (n = 8) was 1.12 and the ratio for the AIDS nonencephalopathy patients (n = 17) was 1.48. The ratio for the 9 controls was 1.57. The encephalopathy group had a significantly lower ratio than both the control (P < .001) and the AIDS nonencephalopathy group (P < .002). The mean white matter ratio for the encephalopathy group (n = 8) was 1.47 and for the AIDS nonencephalopathy group (n = 13) was 1.82 with a control (n = 6) ratio of 1.82. The encephalopathy patients had a lower white matter ratio than the nonencephalopathy (P < .05) patients but the ratio was not different than controls (P < .11). It is concluded that N-acetyl aspartate/creatine ratios are reduced in childhood AIDS encephalopathy and proton magnetic reso...Continue Reading

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Citations

Feb 25, 1999·Journal of Magnetic Resonance Imaging : JMRI·H E MöllerI W Husstedt
May 18, 2011·Neuroradiology·Paulo T C PradoAntonio Carlos Santos
Oct 16, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·R NagarajanM A Keller
Mar 6, 2003·Neurologic Clinics·Anita L Belman
Feb 1, 1997·Pediatric Neurology·S G PavlakisD Lu
Nov 28, 1997·Journal of Child Neurology·Y FrankR A Hyman
Apr 3, 2008·Journal of Magnetic Resonance Imaging : JMRI·Shida BanakarMargaret A Keller
Nov 22, 2019·Neurology. Clinical Practice·Malon Van den HofDasja Pajkrt

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