Magnetic resonance spectroscopy of fiber tracts in children with traumatic brain injury: A combined MRS - Diffusion MRI study

Human Brain Mapping
Emily L DennisRobert F Asarnow

Abstract

Traumatic brain injury can cause extensive damage to the white matter (WM) of the brain. These disruptions can be especially damaging in children, whose brains are still maturing. Diffusion magnetic resonance imaging (dMRI) is the most commonly used method to assess WM organization, but it has limited resolution to differentiate causes of WM disruption. Magnetic resonance spectroscopy (MRS) yields spectra showing the levels of neurometabolites that can indicate neuronal/axonal health, inflammation, membrane proliferation/turnover, and other cellular processes that are on-going post-injury. Previous analyses on this dataset revealed a significant division within the msTBI patient group, based on interhemispheric transfer time (IHTT); one subgroup of patients (TBI-normal) showed evidence of recovery over time, while the other showed continuing degeneration (TBI-slow). We combined dMRI with MRS to better understand WM disruptions in children with moderate-severe traumatic brain injury (msTBI). Tracts with poorer WM organization, as shown by lower FA and higher MD and RD, also showed lower N-acetylaspartate (NAA), a marker of neuronal and axonal health and myelination. We did not find lower NAA in tracts with normal WM organization...Continue Reading

References

Apr 1, 1994·Journal of Clinical and Experimental Neuropsychology·J R Crossen, A N Wiens
Jul 19, 2001·Journal of the International Neuropsychological Society : JINS·J V BaldoE Kaplan
Apr 18, 2003·Pediatric Neurology·Tamara BrennerStephen Ashwal
Jan 1, 1994·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·M W OttoJ F Rosenbaum
Aug 6, 2004·Pediatric Research·Stephen AshwalDaniel Kido
Dec 29, 2004·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Louise ParryPamela Joy
May 3, 2005·NeuroImage·Sheng-Kwei SongRegina C Armstrong
Aug 31, 2006·Journal of Magnetic Resonance Imaging : JMRI·Talin BabikianBarbara A Holshouser
Sep 1, 2006·Developmental Neuroscience·Heather T Keenan, Susan L Bratton
Dec 5, 2006·Archives of Physical Medicine and Rehabilitation·Stephen AshwalBarbara A Holshouser
Oct 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marco CataniDerek K Jones
Oct 22, 2014·Journal of Neurotrauma·Andrew A MaudsleySulaiman Sheriff
Oct 30, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mohammad SabatiAndrew A Maudsley
Jul 17, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emily L DennisRobert F Asarnow
Jul 18, 2015·Journal of Neurotrauma·Kimberly M AndersonJonathan M Levine
Mar 29, 2016·Journal of the International Neuropsychological Society : JINS·Lisa M MoranRobert Asarnow
May 17, 2017·NeuroImage. Clinical·Emily L DennisRobert F Asarnow
Nov 18, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Emily L DennisRobert F Asarnow
Mar 1, 2018·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Emily L DennisRobert F Asarnow

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Citations

Aug 8, 2019·Current Opinion in Pediatrics·Ian C Coulter, Rob J Forsyth
Jun 2, 2020·Human Brain Mapping·Emily L DennisElisabeth A Wilde
Feb 6, 2020·Nature Biomedical Engineering·Jonathan J S RickardPola Goldberg Oppenheimer
Nov 7, 2019·Current Opinion in Pediatrics·Ian C Coulter, Rob J Forsyth
May 6, 2019·Experimental Neurology·Naomi S Sta MariaChristopher C Giza

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