Magnetic resonance spectroscopy of isoflurane kinetics in humans. Part II: Functional localization

British Journal of Anaesthesia
G G LockwoodD K Menon

Abstract

We describe the first experiments to relate the cerebral kinetics of isoflurane (determined by fluorine magnetic resonance spectroscopy) to cerebral function. Using a surface receive coil we found two-compartment kinetics within the head with equilibrium half-times of 3.5 min and approximately 1 h with respect to expired isoflurane concentrations. Using critical fusion flicker frequency as an objective measure of the cerebral effect of isoflurane, we found evidence to identify the fast component as the brain. Responsiveness to command was lost at a brain partial pressure of 0.3% isoflurane. We conclude that the measured cerebral kinetics of isoflurane exactly matched the predictions of the classical perfusion-limited model.

Citations

Sep 2, 2011·Journal of Anesthesia·Kalindi DeSousa, Mohamed Shaaban Ali
Jun 13, 2009·British Journal of Anaesthesia·A R AbsalomM M R F Struys
Jul 23, 2003·World Journal of Surgical Oncology·CS NithyaIqbal M Ahamed
Dec 13, 2006·British Journal of Anaesthesia·S T YeoA Stewart

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.