Magnetic resonance spectroscopy of the human brain

The Anatomical Record
B Ross, S Bluml

Abstract

Magnetic resonance (MR; synonymous with NMR = nuclear magnetic resonance) is a universal physical technique best known for non-invasive detection and anatomical mapping of water protons (H). MR-spectroscopy (MRS) records protons from tissue chemicals other than water, intrinsic phosphorus containing metabolites, sodium, potassium, carbon, nitrogen, and fluorine. MRS is therefore an imaging technique with the potential to record human and animal biochemistry in vivo. As a result of wide availability of MRI equipment in research laboratories and hospitals, MRS is a serious competitor with PET to define normal body composition and its perturbation by pharmacological and pathological events. This article describes practical aspects of in vivo MRS with particular emphasis on the brain, where novel metabolites have been described. A survey of these new aspects of neurochemistry emphasize their practical utility as neuronal and axonal markers, measures of energy status, membrane constituents, and osmolytes, as well as some xenobiotics, such as alcohol. The concept of multinuclear in vivo MRS is illustrated by diagnosis and therapeutic monitoring of several human brain disorders. Although these methods are currently most frequently enc...Continue Reading

References

Feb 15, 1992·The Biochemical Journal·R S Badar-GofferP G Morris
Mar 1, 1992·European Journal of Radiology·B RossT Ernst
May 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K D MerboldtJ Frahm
Jan 1, 1991·Magnetic Resonance Imaging·P A NarayanaD P Flamig
Dec 1, 1989·NMR in Biomedicine·J FrahmH Bruhn
Jul 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmR Sauter
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C C HanstockR G Shulman
Jan 1, 1987·Annals of the New York Academy of Sciences·P A Bottomley
May 1, 1987·Journal of Neuropathology and Experimental Neurology·B A BrodyF H Gilles
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D D Heistad
Jul 30, 1983·Lancet·P A BottomleyR W Redington
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J W PrichardR G Shulman
May 28, 1981·The New England Journal of Medicine·B D RossJ Falconer-Smith
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T R BrownK Ugurbil
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G F MasonE J Novotny
Oct 1, 1994·Annals of Neurology·K A Hossmann
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T Ernst, J Hennig
Jan 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F SchickO Lutz
Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S W Provencher
Apr 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P G WebbR E Hurd
Oct 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R KreisB D Ross
Sep 1, 1993·Journal of Computer Assisted Tomography·T ErnstB D Ross
Jan 1, 1993·Magnetic Resonance Imaging·P ChristiansenH B Larsson
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D L RothmanR H Mattson
Jan 1, 1995·Magnetic Resonance Imaging·L N RynerM A Thomas
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R GruetterP M Andersen
Mar 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S BlumlB D Ross
Mar 1, 1997·Journal of Magnetic Resonance·G Adriany, R Gruetter
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H P HetheringtonJ W Pan
May 15, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R L GreenmanR E Lenkinski

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Citations

Mar 4, 2011·Current Pain and Headache Reports·David Borsook, Lino Becerra
Jun 1, 2005·Brain Research·Rachel Katz-BrullHadassa Degani
Dec 19, 2003·European Journal of Radiology·Alfonso Di CostanzoT Scarabino
Jun 30, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Yael Rosen, Robert E Lenkinski
Dec 17, 2008·Revue neurologique·R GuillevinJ Chiras
Aug 9, 2013·The British Journal of Nutrition·Stéphane V SizonenkoJohn W Sijben
May 14, 2010·Journal of Human Hypertension·T H WesthoffJ Gallinat
Mar 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ciprian CatanaSimon R Cherry
Sep 27, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Timothy C DurazzoDieter J Meyerhoff
Feb 6, 2010·Brain : a Journal of Neurology·Stefan GazdzinskiDieter J Meyerhoff
Oct 24, 2009·The Clinical Journal of Pain·Patrick B WoodJames C Patterson
Nov 10, 2007·Science·Louis N ManganasMirjana Maletic-Savatic
Mar 28, 2012·Journal of Dental Research·G E GerstnerP C Sundgren
Nov 16, 2007·Neuro-oncology·Ashok PanigrahyStefan Blüml
Jul 17, 2010·PloS One·Xiaowei ZhangRussell E Jacobs
Dec 12, 2012·PloS One·Napapon SailasutaUNKNOWN RV254/SEARCH 010 protocol teams
Mar 8, 2013·PloS One·Joseph J GallagherRussell E Jacobs
Oct 8, 2013·PloS One·Małgorzata MarjańskaMelissa Terpstra
Dec 9, 2010·International Journal of Environmental Research and Public Health·Timothy C DurazzoSara Jo Nixon
Sep 14, 2013·Psychopharmacology·Natalie M ZahrAdolf Pfefferbaum
Aug 15, 2009·European Biophysics Journal : EBJ·Marinette van der Graaf
Feb 19, 2014·Psychopharmacology·Joseph O'NeillEdythe D London
Oct 11, 2014·BioMed Research International·Rosella CiurleoSilvia Marino
Nov 15, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Elisabetta PaganiMassimo Filippi

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