Magnetic resonance study on the brain structure and resting-state brain functional connectivity in primary insomnia patients

Medicine
Gang LiYongli Li

Abstract

The aim of the study was to study the changes in brain structure and functional connectivity in primary insomnia (PI) patients, as well as to explore the biological characteristics of PI abnormality and the pathophysiological mechanism underlying the brain structure and the abnormal functional connectivity under depression.Voxel-based morphometry (VBM) technique and resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) techniques were used to investigate the brain structure and rs-fc in PI and light-moderate primary insomnia with depression (PID) patients; healthy individuals were used as the normal control (NC) group. The differences between the 3 groups, the correlation between the brain network connection of the anterior cingulate cortex (ACC), and clinical information were compared.Compared with the NC group, patients in PI and PID groups showed changes in brain structure and brain functional connectivity, which might be related to the pathophysiological mechanism of primary insomnia. PI patients had enhanced connections in the left anterior cingulate cortex/insula, left posterior cingulate, and the right limbic lobe/cingulate gyrus/paracingulate gyrus with ACC. Compared with PI patients, PID patients ...Continue Reading

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