PMID: 9178155May 1, 1997Paper

Magnetic stimulation in Alzheimer's disease

Journal of Neurology
M de CarvalhoM L Luís

Abstract

Alzheimer's disease (AD) is a common cause of dementia in which some clinical motor abnormalities have been described. We used transcranial magnetic stimulation in order to test the hypothesis that the change in the motor cortex might cause modifications in motor excitability. Fourteen mildly to moderately affected AD patients were compared with 11 controls matched for age, height and sex. The motor evoked potential threshold value for the relaxed abductor digiti minimi was lower in the AD patients than in the control group for both left and right hemispheres (P < 0.05). No statistically significant difference was found comparing the left and the right hemispheres thresholds in each population. The mean interside threshold differences were small and not significantly different between patients and controls. The spinal motor neuron excitability, as evaluated by F/M and H/M waves amplitude ratios, showed no difference between the groups, reinforcing the motor cortex increased excitability hypothesis to explain this difference. Degeneration of inhibitory gabaergic terminals might be the basis for the increased cortical excitability in the motor cortex of the Alzheimer patients; postsynaptic changes in the GABAA receptors might als...Continue Reading

Citations

Jan 15, 2008·Experimental Brain Research·Tim WagnerAlvaro Pascual-Leone
Jul 3, 2008·Journal of Neural Transmission·Alessandro MartoranaMariangela Pierantozzi
Aug 17, 2002·Neuroscience Letters·Giovanni PennisiRita Bella
Jul 19, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J LiepertC Weiller
Jul 28, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V Di LazzaroP Tonali
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·V Di LazzaroP A Tonali
Jul 16, 2011·International Journal of Alzheimer's Disease·Andrea GuerraFlorinda Ferreri
Jun 2, 2011·International Journal of Alzheimer's Disease·Petro JulkunenHilkka Soininen
Oct 3, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V Di LazzaroP A Tonali
Jun 6, 2008·Journal of Neuroscience Methods·Petro JulkunenJari Karhu
Jun 7, 2006·The International Journal of Neuroscience·Katica Jovanova-NesicNovera Herbert Spector
Jun 29, 2018·Frontiers in Aging Neuroscience·Joyce Gomes-OsmanAdam J Woods
Jul 3, 2015·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·André V CarreiroSara C Madeira
Nov 10, 2020·Journal of Alzheimer's Disease : JAD·Christopher B PopleNir Lipsman
Feb 23, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adam MederUlf Ziemann
Jan 27, 2017·Translational Neuroscience·Pan WangYuying Zhou
Jul 3, 2021·Journal of Clinical Medicine·Jakub AntczakAgnieszka Słowik

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