Magnetic susceptibility of brain iron is associated with childhood spatial IQ

NeuroImage
Kimberly L H CarpenterHelen Link Egger

Abstract

Iron is an essential micronutrient for healthy brain function and development. Because of the importance of iron in the brain, iron deficiency results in widespread and lasting effects on behavior and cognition. We measured iron in the basal ganglia of young children using a novel MRI method, quantitative susceptibility mapping, and examined the association of brain iron with age and cognitive performance. Participants were a community sample of 39 young children recruited from pediatric primary care who were participating in a 5-year longitudinal study of child brain development and anxiety disorders. The children were ages 7 to 11years old (mean age: 9.5years old) at the time of the quantitative susceptibility mapping scan. The differential abilities scale was administered when the children were 6years old to provide a measure of general intelligence and verbal (receptive and expressive), non-verbal, and spatial performance. Magnetic susceptibility values, which are linearly related to iron concentration in iron-rich areas, were extracted from regions of interest within iron-rich deep gray matter nuclei from the basal ganglia, including the caudate, putamen, substantia nigra, globus pallidus, and thalamus. Controlling for sca...Continue Reading

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Citations

Feb 16, 2017·Biological Research for Nursing·Xiaopeng JiJianghong Liu
Jan 18, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hongjiang WeiChunlei Liu
Mar 16, 2017·Journal of Magnetic Resonance Imaging : JMRI·Yi WangMartin R Prince
Oct 13, 2018·Blood·Fenella J Kirkham, Karin Shmueli
Oct 16, 2020·PloS One·Holly SpenceGordon D Waiter
Dec 17, 2021·Psychological Medicine·Malak AbbasChadi A Calarge

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