Magnetic targeting of smooth muscle cells in vitro using a magnetic bacterial cellulose to improve cell retention in tissue-engineering vascular grafts

Acta Biomaterialia
Sandra L AriasJean-Paul Allain

Abstract

Tissue-engineered vascular grafts (TEVG) use biologically-active cells with or without supporting scaffolds to achieve tissue remodeling and regrowth of injured blood vessels. However, this process may take several weeks because the high hemodynamic shear stress at the damaged site causes cellular denudation and impairs tissue regrowth. We hypothesize that a material with magnetic properties can provide the force required to speed up re-endothelization at the vascular defect by facilitating high cell density coverage, especially during the first 24 h after implantation. To test our hypothesis, we designed a magnetic bacterial cellulose (MBC) to locally target cells in vitro under a pulsatile fluid flow (0.514 dynes cm-2). This strategy can potentially increase cell homing at TEVG, without the need of blood cessation. The MBC was synthesized by an in situ precipitation method of Fe3+ and Fe2+ iron salts into bacterial cellulose (BC) pellicles to form Fe3O4 nanoparticles along the BC's fibrils, followed by the application of dextran coating to protect the embedded nanoparticles from oxidation. The iron salt concentration used in the synthesis of the MBC was tuned to balance the magnetic properties and cytocompatibility of the mag...Continue Reading

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Citations

Mar 27, 2020·Frontiers in Chemistry·Zhongyang LiuPeifu Tang
Dec 29, 2020·Carbohydrate Polymers·Nipaporn Sriplai, Supree Pinitsoontorn
Nov 12, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shuyi Xiao, Liang Chen
Mar 13, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Mahboubeh BouhlouliArash Khojasteh
Jun 14, 2021·Carbohydrate Polymers·Mohamed Abdul Cader Mohamed HaniffaMohd Fahmi Azman
Sep 1, 2021·Colloids and Surfaces. B, Biointerfaces·Xiaoyu WangYakai Feng

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