Magnetically enhanced high-specificity virus detection using bio-activated magnetic nanoparticles with antibodies as labeling markers

Journal of Virological Methods
S Y YangW C Chung

Abstract

This study describes magnetically driven suppression of cross-reactions among molecules. First, the magnetic nanoparticles are coated with bio-probes and dispersed in liquid. The bio-probes can then bind with homologous or heterologous bio-targets. When alternating-current (ac) magnetic fields are applied, magnetic nanoparticles rotate driven by ac magnetic fields. Thus, the bio-targets bound on the surface of magnetic nanoparticles experience a centrifugal force. The centrifugal force can be manipulated by adjusting the angular frequency of the rotating magnetic nanoparticles. The angular frequency is determined by the applied ac magnetic field frequency. Since the binding force for good binding is much higher than that of poor binding, frequency manipulation is needed for the centrifugal force to be higher than the poor-binding force but lower than the good-binding force. Therefore, poor binding which contributes to cross reactions between molecules can be suppressed efficiently by control of the ac magnetic field frequency.

References

Oct 29, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Lutea A A de JongRainer Bischoff

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Citations

Jun 2, 2011·Journal of the American Chemical Society·Oscar R MirandaVincent M Rotello
May 24, 2012·International Journal of Nanomedicine·Kai-Wen HuangHong-Chang Yang
Nov 17, 2012·Advances in Medical Sciences·K NiemirowiczH Car
Feb 18, 2012·Journal of Virological Methods·M W LuJ L Wu
Apr 18, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Jong-Kai HsiaoChin-Tarng Lin
Jun 9, 2016·Sensors·Stefan SchrittwieserJoerg Schotter
Sep 29, 2015·IEEE Transactions on Bio-medical Engineering·Jen-Jie ChiehY Y Lee
Nov 19, 2020·Anais Da Academia Brasileira De Ciências·Gabriel G DE ToledoIseli L Nantes-Cardoso

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