Magnetically responsive siliceous frustules for efficient chemotherapy

Materials Science & Engineering. C, Materials for Biological Applications
Vivek S JavalkotePrashant K Deshmukh

Abstract

In the present investigation, curcumin loaded magnetically active frustules have been reported. The diatoms were cultured and frustules were obtained by chemical and thermal processes. The frustules were rendered magnetically active by incorporation of iron oxide nanoparticle using two different methods involving ferrofluid (CMDM-F) and in situ synthesis (CMDM-I) of iron oxide nanoparticle. These CMDM prepared by two techniques were characterized using FT-IR and vibrating sample magnetometer (VSM) analyses. Particle size and potential were measured using the Malvern Zetasizer. Scanning electron microscopy (SEM) was utilized for studying the surface morphology of CMDM, and in addition to this elemental analysis was also performed for confirming the presence of iron. The cell viability assay was carried out using the HeLa cell line. SEM images showed a change in surface morphology of diatoms before and after rendering magnetic activity. Cell viability assay revealed that CMDM-F had reasonably high cytotoxicity (60.2%) compared to Curcumin (42.1%), DM (1.9%), CDM (44.8%), and CMDM-I (59.9). Both, CMDM-F and CMDM-I showed improved cytotoxicity when compared with pure curcumin. The overall study suggests that the developed CMDM coul...Continue Reading

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Citations

Jul 16, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Abhijeet P PandeyPrashant K Deshmukh
Aug 18, 2018·Advanced Healthcare Materials·Shaheer MaherDusan Losic
Oct 18, 2019·Pharmaceutics·Joachim Delasoie, Fabio Zobi
Apr 20, 2020·Photodiagnosis and Photodynamic Therapy·Javid EsfandyariHossein Naderi-Manesh

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