Magnetically vectored platforms for the targeted delivery of therapeutics to tumors: history and current status

Nanomedicine
Charles SeeneyJim Klostergaard

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) are being developed as vehicles for the selective targeting of therapeutics and bioactive compounds. Presented herein is a brief review of the history of approaches to magnetic-based drug delivery platforms, leading to current concepts of magnetically vectored therapeutics via functionalized SPION-prodrugs. With this background, recent experimental results are discussed that demonstrate the use of shaped external magnetic field gradients, generated by designed configurations of permanent magnets, to drive the concentration/accumulation of modified SPION-prodrug constructs at a tumor site, followed by tumor extravasation and activation of the prodrug within the tumor microenvironment. In order to successfully translate this approach to clinical application, one of the key requirements is the ability to magnetically drive ('vector') the SPION to human-scale tumor settings. In this review, various configurations of permanent magnets are described and models are presented that demonstrate that magnetic field gradients can potentially be focused and extended to lengths of several inches in vivo. This modification thereby increases the range of the delivery platform, and offers the ...Continue Reading

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Citations

Jul 31, 2013·PloS One·Atul A BhardeDonna J Arndt-Jovin
Jun 20, 2012·Nanomedicine·Amanda K Andriola SilvaClaire Wilhelm
May 30, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Jim Klostergaard, Charles E Seeney
Mar 10, 2012·Maturitas·Jim Klostergaard, Charles E Seeney
Feb 11, 2016·Chemical Society Reviews·Neus FeliuWolfgang J Parak
Mar 26, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Arumugam SabareeswaranThrikkovil Variathu Kumary
Jul 16, 2015·Pharmaceutical Patent Analyst·Charles E Seeney
Feb 25, 2015·Nanomedicine·Dominic DocterRoland H Stauber

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Methods Mentioned

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transmission electron microscopy
xenograft

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