Magnetization transfer in hemopoietic bone marrow examined by localized proton spectroscopy

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
F SchickC D Claussen

Abstract

The sensitivity of hemopoietic bone marrow to magnetization transfer is analyzed in 15 healthy volunteers and seven patients with different hematological disorders (inflammation, plasmacytoma, hemopoietic reconstitution after bone marrow transplantation). To obtain sufficient signal-to-noise ratio, a 90 degrees - 180 degrees - 180 degrees double spin echo (PRESS) single voxel spectroscopic method was combined with pulsed magnetization transfer. Several spectra were recorded from each volume element inside the vertebral marrow, alternately with and without prepulses for magnetization transfer. Water signals from marrow with increased content of extracellular water due to inflammation or edema revealed less magnetization transfer effects than marrow with increased intracellular water content due to high cellularity. The preliminary results show magnetization transfer to be a promising tool for the clinically important characterization of the water composition in red bone marrow.

References

Aug 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B S HuA Macovski
Sep 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·K Oshio, R V Mulkern
Aug 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F SchickC D Claussen
Mar 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·P T NiemiS K Koskinen
Jun 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G B PikeD R Enzmann
Jul 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D P FlamigR H Griffey
Jan 1, 1992·Journal of Computer Assisted Tomography·J V HajnalG M Bydder
May 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D BallonJ A Koutcher
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J EngR S Balaban
Jan 1, 1990·Magnetic Resonance Imaging·K E JensenO Henriksen
Apr 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S D Wolff, R S Balaban
Jan 1, 1988·Leukemia Research·R M HenkelmanM Baker
Jan 1, 1987·Annals of the New York Academy of Sciences·P A Bottomley
Jan 1, 1995·Journal of Magnetic Resonance Imaging : JMRI·J Hua, G C Hurst
Oct 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F SchickC D Claussen
Jun 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R M HenkelmanM J Bronskill
Mar 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S H KoenigR Ugolini

❮ Previous
Next ❯

Citations

Apr 15, 2008·European Journal of Radiology·Jürgen MachannFritz Schick
Jun 2, 2017·Journal of Magnetic Resonance Imaging : JMRI·Dimitrios C KarampinosThomas Baum
Sep 3, 2002·Journal of Magnetic Resonance Imaging : JMRI·Carsten AltehoeferMathias Langer
Jun 24, 2006·Journal of Magnetic Resonance Imaging : JMRI·Chun-han HouTony Enright
May 15, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S A RoellD Leibfritz
Feb 13, 2001·Journal of Magnetic Resonance Imaging : JMRI·H KugelW Heindel
Jun 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Houchun Harry HuClaude Sirlin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.