Magnetization transfer of fluoxetine in the human brain using fluorine magnetic resonance spectroscopy

Biological Psychiatry
Wayne L Strauss, Stephen R Dager

Abstract

Fluorine magnetic resonance spectroscopy ((19)F MRS) measurements of fluoxetine and metabolite concentration in the human brain underestimate true drug levels because of a bound, MRS-"invisible" pool of drug molecules. Magnetization transfer (MT) spectroscopy may be a useful technique for characterizing this bound pool of fluoxetine in the brain. Six subjects on consistent daily doses of fluoxetine underwent (19)F MT spectroscopy on a 1.5-T scanner using a train of three preparation pulses at -3000 Hz off resonance with 0.5 W of peak power deposition in tissue. One subject was scanned at multiple time points after initiation of drug therapy. Magnetization transfer signal contrast was quantified using VARPRO-based time domain fitting software. Magnetization transfer signal contrast was quantifiable with mean MT signal depression of 12.5% (SD = 5.0, n = 6). An inverse relationship between brain concentration and the MT signal contrast of fluoxetine was found (r = -.82, Spearman coefficient =.007). This study is the first in vivo application of (19)F MT spectroscopy and the first to demonstrate a quantifiable MT effect for a psychotropic medication in the human brain. Findings suggest that fluoxetine is substantially bound in the ...Continue Reading

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Citations

May 1, 2001·Yeast·C CompagnoD Porro
Dec 6, 2012·Investigative Radiology·Martijn WoltersWalter H Backes
Feb 13, 2002·Biological Psychiatry·In Kyoon Lyoo, Perry F Renshaw
Apr 5, 2013·Clinical Microbiology Reviews·Daniel GonzalezHartmut Derendorf
Feb 18, 2010·Progress in Nuclear Magnetic Resonance Spectroscopy·Su Xu, Jun Shen

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