Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Neurochemistry International
Sveinung FjærStig Wergeland

Abstract

Magnetization transfer ratio (MTR) is a magnetic resonance imaging (MRI) method which may detect demyelination not detected by conventional MRI in the central nervous system of patients with multiple sclerosis (MS). A decrease in MTR value has previously been shown to correlate to myelin loss in the mouse cuprizone model for demyelination. In this study, we investigated the sensitivity of MTR for demyelination in the myelin oligodendrocyte (MOG) 1-125 induced experimental autoimmune encephalomyelitis (EAE) mouse model. A total of 24 female c57Bl/6 mice were randomized to a control group (N = 6) or EAE (N = 18). MTR images were obtained at a preclinical 7 Tesla Bruker MR-scanner before EAE induction (baseline), 17-19 days (midpoint) and 31-32 days (endpoint) after EAE induction. Mean MTR values were calculated in five regions of the brain and compared to weight, EAE severity score and myelin content assessed by immunostaining for proteolipid protein and luxol fast blue, lymphocyte and monocyte infiltration and iron deposition. Contrary to what was expected, MTR values in the EAE mice were higher than in the control mice at the midpoint and endpoint. No significant difference in myelin content was found according to histo- or imm...Continue Reading

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Citations

Oct 28, 2017·Brain Imaging and Behavior·Sandra AlbaneseMarcello Mancini
Dec 21, 2016·Brain Plasticity·Alex L MacKay, Cornelia Laule
Oct 22, 2020·ELife·Matteo ManciniNikola Stikov
Nov 16, 2020·NeuroImage·Chris W J van der WeijdenErik F J de Vries
Oct 14, 2020·Neurobiology of Aging·Andrew J CarradusChristopher R Madan
Jun 4, 2021·NeuroImage. Clinical·Bianca OlivieriPia Wintermark

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