Magnetization Transfer Ratio in Peripheral Nerve Tissue: Does It Depend on Age or Location?

Investigative Radiology
Jennifer KollmerSabine Heiland

Abstract

Magnetization transfer contrast imaging provides indirect information on the concentration of "bound" water protons and their interactions with "free" water molecules. The purpose of this study is to analyze location- and age-dependent changes in the magnetization transfer ratio (MTR) of lower extremity nerves. Ten younger (20-32 years) and 5 older (50-63 years) healthy volunteers underwent magnetization transfer contrast imaging at 3 Tesla Two 3-dimensional gradient echo sequences with and without an off-resonance saturation pulse (repetition time: 58 milliseconds; echo time: 2.46 milliseconds; band width: 530 Hz/Px; flip angle: α = 7°) were acquired at 3 different locations covering the proximal thigh to the distal lower leg in the group of younger volunteers and at 2 different locations covering the proximal to distal thigh in the group of older volunteers. Sciatic and tibial nerve regions of interest (ROIs) were manually drawn and additional ROIs were placed in predetermined muscles. Magnetization transfer ratios were extracted from respective ROIs and calculated for each individual and location. In young volunteers, mean values of nerve and muscle MTR were not different between the proximal thigh (nerve: 20.34 ± 0.91; musc...Continue Reading

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Citations

Dec 25, 2019·Annals of Clinical and Translational Neurology·Michael PridmoreRichard Dortch
Apr 26, 2020·Annals of Clinical and Translational Neurology·Jennifer KollmerMarkus Weiler
Nov 9, 2019·F1000Research·Yongsheng ChenJun Li
Sep 13, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J KollmerM Weiler
Dec 4, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jennifer Kollmer, Martin Bendszus
Dec 17, 2021·PloS One·Scott A HolmesDavid Borsook

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