PMID: 11915982Mar 28, 2002Paper

Magnetocardiographic and magnetic resonance imaging for noninvasive localization of ventricular arrhythmia origin in a model of nonischemic cardiomyopathy

Pacing and Clinical Electrophysiology : PACE
Pär Lennart AgrenLennart Bergfeldt

Abstract

Ventricular arrhythmia may in myocardial failure arise as a consequence of remodeling related to hypertrophy and dilatation. In surgically repaired tetralogy of Fallot (TOF), which carries a substantial risk for ventricular arrhythmias and sudden death, the situation is even more complex and several potential arrhythmia mechanisms exist. The authors wanted to test a completely noninvasive localization technique, magnetocardiography (MCG) and magnetic resonance imaging (MRI), to define the origin of ventricular ectopic beats (VEBs) in this model of nonischemic cardiomyopathy. The study included 84 patients with surgically repaired TOF, all 11 subjects with VEBs Lown grade > or = 2 on a 24-hour Holter were included. From 37-channel MCG registrations, the underlying current dipole was computed for the VEBs, and for anatomic correlation MRIs were produced. Eight patients had VEBs of altogether 11 morphologies during the MCG recording. The RVOT was the origin of 6 VEBs, while 4 originated from the RV free wall, and 1 VEB could not be localized. Applying this completely noninvasive technique, it was possible to define different origins of RV ectopies in a complex heart model. Thus, VEBs originated from the RVOT, suggesting a relation...Continue Reading

Citations

Sep 13, 2002·NMR in Biomedicine

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