DOI: 10.1101/461855Nov 5, 2018Paper

Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies

BioRxiv : the Preprint Server for Biology
Amanda WickensJacob T Robinson

Abstract

A fundamental challenge for bioelectronics is to deliver power to miniature devices inside the body. Wires are common failure points and limit device placement. On the other hand, wireless power by electromagnetic or ultrasound waves must overcome absorption by the body and impedance mismatches between air, bone, and tissue. In contrast, magnetic fields suffer little absorption by the body or differences in impedance at interfaces between air, bone, and tissue. These advantages have led to magnetically-powered stimulators based on induction or magnetothermal effects. However, fundamental limitations in these power transfer technologies have prevented miniature magnetically-powered stimulators from applications in many therapies and disease models because they do not operate in clinical "high-frequency" ranges above 50 Hz. Here we show that magnetoelectric materials - applied in bioelectronic devices - enable miniature magnetically-powered neural stimulators that can operate up to clinically-relevant high-frequencies. As an example, we show that ME neural stimulators can effectively treat the symptoms of a hemi-Parkinsons disease model in freely behaving rodents. We further demonstrate that ME-powered devices can be miniaturized...Continue Reading

Citations

May 22, 2020·Frontiers in Neuroscience·James Z FanSunil A Sheth

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