Magnetoencephalographic and magnetic resonance spectroscopy evidence of regional functional abnormality in mesial temporal lobe epilepsy

Brain Topography
Jerry J ShihRoland R Lee

Abstract

Mesial temporal lobe epilepsy (mTLE) with mesial temporal sclerosis (MTS) is a recognized epilepsy syndrome which is successfully treated with mesial temporal lobe resection. However, recent studies suggest that mTLE is more than a "focal" disease process. The objective of our study was to determine the presence and extent of functional abnormalities outside of a defined structural abnormality in epilepsy patients with mTLE. We used a prospective age-matched controlled design to study eight consecutive patients with MTS who were undergoing epilepsy surgery evaluation. Magnetoencephalography was used to localize the sources of electromagnetic abnormality. Proton magnetic resonance spectroscopy ((1)H-MRS) measured integrated peak areas for N-acetyl compounds (NAA) and choline-containing compounds (Cho) to determine regions of metabolic abnormality. All eight subjects had predominant electromagnetic abnormality in the temporal lobe ipsilateral to the MTS. All eight subjects had lower NAA/Cho ratios in the region of electromagnetic abnormality when compared to the homologous contralateral region (P < 0.001). Four subjects had predominant MEG spiking outside the mesial temporal region. Surgery-free outcome for the group with neuroim...Continue Reading

References

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Aug 28, 2001·Brain : a Journal of Neurology·F Rosenow, H Lüders
Apr 16, 2002·Epilepsia·Masaki IwasakiTakashi Yoshimoto
Oct 9, 2002·Epilepsia·Susanne G MuellerMichael W Weiner
Mar 4, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Ayako Ochi, Hiroshi Otsubo

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Citations

Sep 8, 2012·Epilepsy Research and Treatment·Katherine C NickelsElaine C Wirrell
May 31, 2011·Expert Opinion on Drug Safety·Sherifa Ahmad Hamed
Apr 22, 2012·World Journal of Psychiatry·Sherifa A HamedMostafa M Abdellah

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