Magnetoencephalographic Characteristics of Cortical Dysplasia in Children

Pediatric Neurology
Nitin AgarwalAjay Gupta

Abstract

Magnetoencephalography has emerged as a tool for preoperative evaluation in children. We studied magnetoencephalography characteristics in subtypes of focal cortical dysplasia and correlated the findings with postoperative seizure outcome. Inclusion criteria were children ≤18 years who underwent magnetoencephalography during the preoperative evaluation followed by epilepsy surgery and a histopathologic diagnosis of focal cortical dysplasia between February 2008 and February 2013. Patient demographics, MRI, video electroencephalography, and magnetoencephalography data were reviewed. Postoperative seizure outcome data were categorized per International League against Epilepsy definitions. Of 178 magnetoencephalography studies performed in children during the study period, 33 patients met inclusion criteria. Focal cortical dysplasia type I, II, and III were found on histopathology in 52%, 39%, and 9% of patients, respectively. Thirty patients had positive magnetoencephalography dipoles, including all patients with focal cortical dysplasia type II and III and 82% of patients with focal cortical dysplasia type I. Three patients had magnetoencephalography unique spikes. Brain MRI lesions were noted preoperatively in 21 patients (64%)...Continue Reading

Citations

Mar 27, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jie ChenChun-Qing Zhang
Feb 26, 2019·F1000Research·Priya SharmaRobert Greenwood
Aug 9, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alican Tahta, Mehmet Turgut
Mar 30, 2021·Expert Review of Neurotherapeutics·Hiroshi OtsuboElysa Widjaja

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