Magnetoencephalographic parietal delta dipole density in mild cognitive impairment: preliminary results of a method to estimate the risk of developing Alzheimer disease

Archives of Neurology
Alberto FernándezTomás Ortiz

Abstract

Subjects with mild cognitive impairment (MCI) are at a higher risk of experiencing Alzheimer disease (AD). Magnetoencephalographic temporoparietal dipole densities of low-frequency activity are good predictors of individuals' cognitive status, and might be a useful tool to investigate the conversion from MCI to AD. To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD. Whole-head magnetoencephalographic recordings were obtained from 19 probable AD patients, 17 MCI patients, and 17 healthy control subjects. The generators of focal magnetic slow waves were located using a single moving dipole model. Left parietal delta dipole density permitted a reliable classification of AD and MCI patients. The MCI patients were divided into 2 groups based on the median left parietal delta dipole density, and were followed up for 2 years. The estimated relative risk of conversion to AD was increased by 350% in those MCI patients with high left parietal delta dipole density scores. Results confirmed the important role of parietal delta dipole density in the evaluation of AD and MCI. A magnetoencephalographic-based assessment of AD and MCI patients might be considered a useful clinical test in the ne...Continue Reading

Citations

Jun 24, 2011·Brain Imaging and Behavior·Vera Maria LeirerIris-Tatjana Kolassa
Mar 31, 2012·Brain Connectivity·Ricardo BajoFernando Maestu
Nov 22, 2011·Revista española de geriatría y gerontología·Alberto FernándezFernando Maestú
Oct 31, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Lorena R R GianottiUrsula Schreiter-Gasser
Apr 7, 2007·Annals of the New York Academy of Sciences·Leslie S Prichep
May 7, 2011·International Journal of Alzheimer's Disease·Edward ZamriniJames T Becker
Jun 1, 2016·Frontiers in Human Neuroscience·Marjolein M A EngelsElisabeth C W van Straaten
Feb 6, 2008·Computer Methods and Programs in Biomedicine·Jesús PozaAgustín Mayo
Feb 3, 2007·American Journal of Alzheimer's Disease and Other Dementias·José R CriadoShirley M Otis
Jun 19, 2009·Clinical EEG and Neuroscience·David S Cantor, Robert Chabot
Mar 15, 2011·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Fernando MaestúAngel Nevado
Nov 13, 2007·Annals of Biomedical Engineering·Jesús PozaClara I Sánchez
May 23, 2008·American Journal of Physical Medicine & Rehabilitation·Robert A BoyajianRichard A Smith
May 13, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Eduardo M CastilloAndrew C Papanicolaou
Aug 5, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Willem de HaanPhilip Scheltens
Jul 3, 2009·Alzheimer Disease and Associated Disorders·Ariadna BesgaTomás Ortiz
May 28, 2010·Alzheimer Disease and Associated Disorders·Alberto FernándezTomás Ortiz
Sep 24, 2010·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Ryouhei IshiiMasatoshi Takeda
Sep 9, 2010·Annals of Biomedical Engineering·Joan Francesc AlonsoRoberto Hornero
Mar 10, 2018·Brain : a Journal of Neurology·Akinori NakamuraTakashi Kato
Apr 12, 2016·Journal of Alzheimer's Disease : JAD·María Eugenia LópezAlberto Fernández
Mar 13, 2014·Journal of Neural Engineering·Jesús PozaRoberto Hornero
Sep 5, 2020·GeroScience·María Eugenia LópezAlberto Fernández
Aug 31, 2018·Frontiers in Neuroscience·David López-SanzFernando Maestú
Nov 10, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anto I BagićRichard C Burgess
Apr 28, 2020·Neuroimaging Clinics of North America·Fernando Maestú, Alberto Fernández
Feb 12, 2020·Journal of Neuroscience Methods·Pietro A CicaleseYingchun Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Claudio BabiloniPaolo M Rossini
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Donatella MattiaMaria Grazia Marciani
Alzheimer Disease and Associated Disorders
B SaletuG Litschauer
© 2021 Meta ULC. All rights reserved