Magnetoencephalographic Recordings in Infants: A Retrospective Analysis of Seizure-Focus Yield and Postsurgical Outcomes

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
Stephanie Garcia-TarodoGretchen K Von Allmen

Abstract

Magnetoencephalography (MEG) is often incorporated into the presurgical work-up of children with pharmacoresistant epilepsy. There is growing literature on its role in improving selection for epilepsy surgery, particularly when brain MRI is "non-lesional" or in patients with recurrence or intractable seizures after epilepsy surgery. There are, however, no reports on the extrapolation of its role in the presurgical decision-making process of infants. We performed a retrospective analysis of infants who underwent MEG over a 10-year period at our center for presurgical work-up. We reviewed medical records to ascertain seizure history, work-up procedures including brain MRI and scalp EEG, and in the case of surgery, intracranial recordings, operative notes, and follow-up outcomes. We identified 31 infants (<2 years of age) who underwent MEG recordings. Despite EEG interictal readings showing patterns of generalized dysfunction in 80%, MEG was able to pinpoint the foci of epileptic activity in 45%. In the MRI-negative group, 44% had focal lateralized interictal spikes on MEG. The sensitivity of MEG to detect interictal epileptiform activity was 90%, and its ability to provide additional information was 28%. Among 18 infants who had ...Continue Reading

References

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Jul 1, 2017·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Sumiya ShibataRichard C Burgess

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Citations

Aug 3, 2019·Brain : a Journal of Neurology·Stefan RamppMichael Buchfelder
Sep 29, 2019·Brain : a Journal of Neurology·Richard C Burgess
Feb 26, 2019·F1000Research·Priya SharmaRobert Greenwood
Nov 10, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anto I Bagić, Richard C Burgess
Nov 10, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·John C Mosher, Michael E Funke
Jun 22, 2021·Frontiers in Human Neuroscience·Michael W WatkinsGretchen Von Allmen

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