Magnetoencephalography for epileptic focus localization in a series of 1000 cases

Brain : a Journal of Neurology
Stefan RamppM Buchfelder

Abstract

The aim of epilepsy surgery in patients with focal, pharmacoresistant epilepsies is to remove the complete epileptogenic zone to achieve long-term seizure freedom. In addition to a spectrum of diagnostic methods, magnetoencephalography focus localization is used for planning of epilepsy surgery. We present results from a retrospective observational cohort study of 1000 patients, evaluated using magnetoencephalography at the University Hospital Erlangen over the time span of 28 years. One thousand consecutive cases were included in the study, evaluated at the University Hospital Erlangen between 1990 and 2018. All patients underwent magnetoencephalography as part of clinical workup for epilepsy surgery. Of these, 405 underwent epilepsy surgery after magnetoencephalography, with postsurgical follow-ups of up to 20 years. Sensitivity for interictal epileptic activity was evaluated, in addition to concordance of localization with the consensus of presurgical workup on a lobar level. We evaluate magnetoencephalography characteristics of patients who underwent epilepsy surgery versus patients who did not proceed to surgery. In operated patients, resection of magnetoencephalography localizations were related to postsurgical seizure ou...Continue Reading

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Citations

Oct 31, 2019·Brain : a Journal of Neurology·Nicole van Klink, Maeike Zijlmans
Mar 1, 2020·Annals of Clinical and Translational Neurology·Umesh VivekanandaMatthew C Walker
Feb 13, 2020·Current Opinion in Neurology·Birgit Frauscher
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Nov 10, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anto I Bagić, Richard C Burgess
Nov 10, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anto I Bagić, Richard C Burgess
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