Magnetospinography visualizes electrophysiological activity in the cervical spinal cord

Scientific Reports
Satoshi SumiyaAtsushi Okawa

Abstract

Diagnosis of nervous system disease is greatly aided by functional assessments and imaging techniques that localize neural activity abnormalities. Electrophysiological methods are helpful but often insufficient to locate neural lesions precisely. One proposed noninvasive alternative is magnetoneurography (MNG); we have developed MNG of the spinal cord (magnetospinography, MSG). Using a 120-channel superconducting quantum interference device biomagnetometer system in a magnetically shielded room, cervical spinal cord evoked magnetic fields (SCEFs) were recorded after stimulation of the lower thoracic cord in healthy subjects and a patient with cervical spondylotic myelopathy and after median nerve stimulation in healthy subjects. Electrophysiological activities in the spinal cord were reconstructed from SCEFs and visualized by a spatial filter, a recursive null-steering beamformer. Here, we show for the first time that MSG with high spatial and temporal resolution can be used to map electrophysiological activities in the cervical spinal cord and spinal nerve.

References

Oct 1, 1991·Electroencephalography and Clinical Neurophysiology·I HashimotoS Yokoyama
Jun 1, 1989·Biophysical Journal·L TrahmsP Aust
Jun 1, 1982·Electroencephalography and Clinical Neurophysiology·R KakigiY Kuroiwa
Apr 4, 1980·Science·J P WikswoJ A Freeman
Feb 14, 1998·The Journal of Bone and Joint Surgery. British Volume·M MatsumotoH Shiga
Sep 29, 1998·Electroencephalography and Clinical Neurophysiology·B M MackertP Marx
Feb 13, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B M MackertG Curio
Jul 19, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·B M MackertG Curio
Mar 7, 2002·Spine·Shigenori KawabataKenichi Shinomiya
Mar 19, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Morris A Fisher
Dec 5, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yuko FukuokaOmi Terasaki
Aug 6, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yuko FukuokaKenichi Shinomiya
Oct 14, 2004·Spine·Josef BednarikBoleslav Prokes
Nov 18, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bruno-Marcel Mackert
Jul 27, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Martin SutterJiri Dvorak
Aug 2, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Tetsuya Tamaki, Seiji Kubota
Jan 15, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Josef BednarikDagmar Kratochvilova
Mar 14, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shoji TomizawaKenichi Shinomiya
Feb 23, 2010·IEEE Transactions on Bio-medical Engineering·Isamu Kumihashi, Kensuke Sekihara
Apr 21, 2010·Experimental Biology and Medicine·Ranjith S Wijesinghe
May 7, 2010·The Neurologist·Jennifer A Tracy, J D Bartleson
Jun 19, 2010·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Masaki TomoriAtsushi Okawa
Sep 17, 2011·The Journal of Hand Surgery, European Volume·K O'SheaS W Wolfe
Jan 31, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Senichi IshiiAtsushi Okawa
Feb 4, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Fumihiko KatoTakayoshi Ueta
Dec 4, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sukhvinder Kalsi-RyanMichael G Fehlings
Aug 7, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Benjamin M EllingsonLangston T Holly
Aug 22, 2013·Spine·Spyridon K KaradimasMichael G Fehlings
Sep 24, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·D B MacdonaldUNKNOWN American Society of Neurophysiological Monitoring
Oct 11, 2013·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Taishi WatanabeKensuke Sekihara
Mar 15, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Spyridon K KaradimasMichael G Fehlings
Apr 9, 2014·The Spine Journal : Official Journal of the North American Spine Society·Keiji NagataMunehito Yoshida
Oct 22, 2014·Acta neurochirurgica·Ozlem KirazliSafiye Cavdar
Oct 29, 2014·World Journal of Radiology·Chuan ZhangHan-Feng Yang
Apr 12, 2016·Journal of Neural Engineering·Kensuke SekiharaSrikantan S Nagarajan

❮ Previous
Next ❯

Citations

Mar 15, 2020·Sensors·Dmitry MurzinValeria Rodionova
Jan 16, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Miho AkazaTakanori Yokota
Apr 17, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kyohei SakakiAtsushi Okawa

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.