Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus

The American Journal of Cardiology
A S KrolewskiC R Kahn

Abstract

The risk of premature coronary artery disease (CAD) and its determinants were investigated in a cohort of 292 patients with juvenile-onset, insulin-dependent diabetes mellitus (IDDM) who were followed for 20 to 40 years. Although patients with juvenile-onset IDDM had an extremely high risk of premature CAD, the earliest deaths due to CAD did not occur until late in the third decade of life. After age 30 years, the mortality rate due to CAD increased rapidly, equally in men and women, and particularly among persons with renal complications. By age 55 years the cumulative mortality rate due to CAD was 35 +/- 5%. This was far higher than the corresponding rate for nondiabetic persons in the Framingham Heart Study, 8% for men and 4% for women. Angina and acute nonfatal myocardial infarction followed a similar pattern, as did asymptomatic CAD detected by stress test, so that their combined prevalence rate was 33% among survivors aged 45 to 59 years. Age at onset of IDDM and the presence of eye complications did not contribute to risk of premature CAD. This pattern suggests that juvenile-onset diabetes and its renal complications are modifiers of the natural history of atherosclerosis in that although they profoundly accelerate progr...Continue Reading

References

Oct 1, 1979·Annals of Surgery·J S NajarianB G Sommer
Feb 20, 1986·The New England Journal of Medicine·R Ross
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M W MajeskyM R Juchau
May 17, 1971·JAMA : the Journal of the American Medical Association·J J McNamaraR T Cutting
Sep 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·H C McGill
Mar 1, 1984·Progress in Cardiovascular Diseases·N B Ruderman, C Haudenschild
Dec 1, 1983·The Tohoku Journal of Experimental Medicine·M ShibataH Iwata
Mar 20, 1980·The New England Journal of Medicine·J M SosenkoK H Gabbay
Jan 1, 1981·Diabetes Care·J A ColwellP V Halushka
Aug 5, 1982·The New England Journal of Medicine·P J NestelM H Tan
Dec 23, 1982·The New England Journal of Medicine·A R Feinstein, R I Horwitz
Feb 14, 1980·The New England Journal of Medicine·S M FactorT Minase
Nov 1, 1980·Scientific American·R A Stallones
Jan 1, 1981·Diabetes Care·R J Jarrett, H Keen
Jul 18, 1953·Journal of the American Medical Association·W F ENOSJ BEYER

❮ Previous
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Citations

Jul 13, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·T JosephJ Marco
Feb 1, 1990·Diabetes/metabolism Reviews·F L Dunn
Jul 1, 1994·Diabetologia·S LahdenperäM R Taskinen
Mar 2, 2005·Irish Journal of Medical Science·G H Tomkin
Dec 13, 2006·Reviews in Endocrine & Metabolic Disorders·R Paul Wadwa
Mar 9, 2006·Current Diabetes Reports·Helen Colhoun
Apr 25, 2012·Journal of Cardiovascular Translational Research·Janet K Snell-Bergeon, Kristen Nadeau
Jan 1, 1994·Chemistry and Physics of Lipids·S M HaffnerD L Rainwater
Dec 31, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·J L ReverterA Sanmartí
Jan 1, 1995·Molecular Aspects of Medicine·M J Halpern
Dec 1, 1995·Diabetes Research and Clinical Practice·S F O'BrienK G Stanton
Dec 1, 1995·Diabetes Research and Clinical Practice·E I PortueseT J Orchard
Jul 1, 1996·Diabetes Research and Clinical Practice·S M FactorE H Sonnenblick
Sep 1, 1992·Journal of the American College of Cardiology·R M Jacoby, R W Nesto
Jun 16, 2005·Diabetes Research and Clinical Practice·Jamal AhmadIbne Ahmad
Feb 18, 2004·The Journal of Laboratory and Clinical Medicine·Patrizia FabbiSilvano Garibaldi
Nov 14, 2000·The American Journal of Cardiology·P PajunenM Syvänne
Jun 8, 2001·Atherosclerosis·T ShojiY Nishizawa
Aug 10, 2000·Journal of the American College of Cardiology·M J MullenJ E Deanfield
Dec 29, 2000·Journal of the American College of Cardiology·H M ColhounJ H Fuller
Feb 25, 2003·Journal of the American College of Cardiology·Lloyd W Klein, Sandeep Nathan
Mar 21, 1998·Journal of the American College of Cardiology·F K TimimiM A Creager
May 15, 1998·Journal of the American College of Cardiology·M J MullenJ E Deanfield

❮ Previous
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