Abstract
The European Stroke Prevention Study showed greater stroke prevention for Aggrenox than either for aspirin or dipyridamole alone. To test whether Aggrenox has superior antiplatelet properties to aspirin alone we conducted the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Forty patients with prior ischemic stroke not taking aspirin for at least 30 days were randomized to Aggrenox (2 pills/daily) or aspirin (81 mg plus matching placebo/daily) for 30 days. Platelet function was assessed at baseline, 24 h, and days 3, 7, 15, and 30 by aggregometry, flow cytometry and cartridge-based analyzers. Both Aggrenox and aspirin provided fast and sustained platelet inhibition. Aggrenox(R), however, especially after 15 days, showed significant prolongation of the closure time (P=0.04), diminished expression of platelet/endothelial cell adhesion molecule-1 (PECAM-1) (P=0.01), glycoprotein IIb (GPIIb) antigen (P=0.02), and GPIIb/IIIa activity (P=0.01) by PAC-1 C antibody, CD63 (P=0.03), as well as inhibition of Protease Activated Receptors (PAR-1) associated with intact (SPAN12, P=0.01) and cleaved (WEDE15, P=0.01) thrombin receptors as compared with aspirin. Surprisingly, GPIb expression increased, especially after aspirin. In the ...Continue Reading
References
Mar 22, 1991·Cell·T K VuS R Coughlin
Jun 18, 1991·European Journal of Pharmacology·H BultA G Herman
Aug 1, 1990·British Journal of Clinical Pharmacology·T H MüllerW G Eisert
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·V M DixitW A Frazier
Apr 15, 1989·The Biochemical Journal·S Laferte, J W Dennis
May 14, 1987·The New England Journal of Medicine·G A FitzGerald
Jan 1, 1981·European Journal of Clinical Pharmacology·G G Neri SerneriA Morettini
Feb 1, 1995·Free Radical Biology & Medicine·L IulianoF Violi
Nov 1, 1994·Atherosclerosis·M L SelleyN G Ardlie
Feb 1, 1994·The Journal of Clinical Investigation·G H van ZantenJ J Sixma
Mar 1, 1994·Journal of the American College of Cardiology·J P SinghG P Dubé
Mar 20, 1993·Annals of the New York Academy of Sciences·K A Ault
Nov 1, 1996·Journal of the Neurological Sciences·H C DienerA Lowenthal
Jan 4, 1998·Kidney International·J Himmelfarb, L Couper
May 13, 1998·British Journal of Clinical Pharmacology·C R Gibbs, G Y Lip
May 14, 1998·Seminars in Thrombosis and Hemostasis·E F MammenD J Nugent
Feb 9, 1999·Circulation·J W SmithB S Coller
Mar 17, 1999·The Journal of Clinical Investigation·M L KahnS R Coughlin
Apr 6, 1999·Trends in Cardiovascular Medicine·L D CupitW F Bahou
Jun 14, 2000·European Journal of Pharmacology·J P De La CruzF Sánchez de la Cuesta
Sep 9, 2000·Current Opinion in Cell Biology·J Lawler
Jan 12, 2001·Journal of the American College of Cardiology·O O AkinboboyeS R Bergmann
Sep 12, 2001·Neurology·T H Müller
Sep 12, 2001·Neurology·W G Eisert
Jan 12, 2002·BMJ : British Medical Journal·UNKNOWN Antithrombotic Trialists' Collaboration
May 25, 2002·The Journal of Laboratory and Clinical Medicine·Kenneth A SchwartzJohn M Davis
Aug 13, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Takuya IchiiYoshiki Nishizawa
Feb 20, 2003·Biochemistry·Alicia J SchadeJing-fei Dong
Apr 1, 2003·American Journal of Hematology·Victor L SerebruanyDavid C Sane
Apr 16, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Marcus E McKenzieVictor L Serebruany
May 14, 2004·Thrombosis Research·Victor L SerebruanyCharles H Hennekens
Citations
Apr 26, 2006·Current Treatment Options in Cardiovascular Medicine·Christopher D Booze, Victor L Serebruany
Sep 22, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W O TobinD J H McCabe
Feb 1, 2007·Cardiology·Victor L SerebruanyDan Atar
Dec 10, 2009·Vascular Health and Risk Management·Rakesh K SharmaGirish Bhatt
Mar 1, 2005·Drugs·Jesse Weinberger
Jan 18, 2014·Journal of Cardiovascular Translational Research·Roza Badr EslamSimon Panzer
Dec 29, 2013·International Journal of Pharmaceutics·Admassu AbebeAlberto M Cuitiño
Jan 15, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Roza Badr EslamSimon Panzer
Oct 27, 2012·The Annals of Thoracic Surgery·Victor A FerrarisUNKNOWN Society of Thoracic Surgeons
Mar 18, 2008·Clinical Therapeutics·Victor L SerebruanyDaniel F Hanley
Mar 10, 2009·Fundamental & Clinical Pharmacology·Victor L SerebruanyJames J Ferguson
Jan 13, 2011·British Journal of Haematology·William Oliver TobinDominick J H McCabe
Aug 22, 2006·Pharmacology & Therapeutics·Marie LordkipanidzéJean G Diodati
Nov 18, 2005·American Heart Journal·Victor L SerebruanyJames J Ferguson
Jun 5, 2015·Platelets·Soon Tjin LimDominick J H McCabe
Feb 22, 2012·Pharmaceutical Development and Technology·Divyakant DesaiPeter Timmins
Apr 25, 2007·Circulation·Andrew O Maree, Desmond J Fitzgerald
Jun 21, 2012·Stroke; a Journal of Cerebral Circulation·Jeremiah P DeptaDeepak L Bhatt
Dec 13, 2005·Cerebrovascular Diseases·Victor SerebruanyDan Hanley
Aug 1, 2007·Expert Review of Pharmacoeconomics & Outcomes Research·Darya MalininaVictor Serebruany
Jul 28, 2005·The Journal of Pharmacology and Experimental Therapeutics·Subrata ChakrabartiJane E Freedman
Sep 3, 2011·Cardiovascular Therapeutics·Jesse DawsonMatthew R Walters
Jun 11, 2020·Journal of Neurology·Soon Tjin LimDominick J H McCabe