Magnitude of Hematoma Volume Measurement Error in Intracerebral Hemorrhage

Stroke; a Journal of Cerebral Circulation
D Rodriguez-LunaPREDICT/Sunnybrook ICH CTA Study Group

Abstract

Limiting intracerebral hemorrhage (ICH) and intraventricular hemorrhage (IVH) expansion is a common target for acute ICH studies and, therefore, accurate measurement of hematoma volumes is required. We investigated the amount of hematoma volume difference between computed tomography scans that can be considered as measurement error. Five raters performed baseline (<6 hours) and 24-hour total hematoma (ICH+IVH) computer-assisted volumetric analysis from 40 selected ICH patients from the Predicting Hematoma Growth and Outcome in Intracerebral Hemorrhage Using Contrast Bolus CT (PREDICT) study cohort twice. Estimates of intrarater and interrater reliability are expressed as intraclass correlation coefficients and minimum detectable difference (MDD). Total hematoma volumetric analyses had excellent intra- and interrater agreements (intraclass correlation coefficients 0.994 and 0.992, respectively). MDD for intra- and interrater volumes was 6.68 and 7.72 mL, respectively, and were higher the larger total hematoma volume was and in patients with subarachnoid hemorrhage or IVH. MDD for total hematoma volume measurement of 10.4 mL was found in patients with largest hematoma volumes. In patients with subarachnoid hemorrhage or IVH, MDD ...Continue Reading

References

Feb 25, 2005·The New England Journal of Medicine·Stephan A MayerUNKNOWN Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators
Apr 26, 2006·Neurology·S M DavisUNKNOWN Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators
May 26, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Jayme C KosiorUNKNOWN PREDICT/Sunnybrook CTA ICH study investigators
May 17, 2012·Stroke; a Journal of Cerebral Circulation·Dar DowlatshahiUNKNOWN PREDICT/Sunnybrook ICH-CTA study group

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Citations

Jul 6, 2017·Radiology·David Rodriguez-LunaCarlos A Molina
Jun 20, 2018·Stroke; a Journal of Cerebral Circulation·Sandro MariniUNKNOWN International Stroke Genetics Consortium
Nov 19, 2019·Stroke; a Journal of Cerebral Circulation·Natasha IronsideEdward Sander Connolly
Sep 1, 2017·European Stroke Journal·Vignan YogendrakumarDar Dowlatshahi
Feb 7, 2020·Neurocritical Care·Björn M HansenUNKNOWN MISTIE and CLEAR Investigators
Jun 20, 2021·Neurology·Vignan YogendrakumarDar Dowlatshahi
Sep 3, 2021·JAMA Network Open·Stephan A MayerUNKNOWN CNS Bleeding/Neurosurgery Subgroup of the NHLBI Hemostasis Trials Outcomes Working Group
Sep 29, 2021·Journal of Theoretical Biology·Jiayu Wang, Stephen J Payne

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