Magnitude of risk for nodal metastasis associated with lymphvascular space invasion for endometrial cancer

Gynecologic Oncology
Soledad JorgeJason D Wright

Abstract

While lymphvascular space invasion (LVSI) is a risk factor for nodal metastasis in endometrial cancer, the magnitude of risk is poorly described. We examined the risk of nodal metastasis associated with LVSI for various combinations of tumor grade and depth of invasion and examined the effect of LVSI on survival. We identified patients with T1A (<50% myoinvasion) and T1B (>50% myoinvasion) endometrioid adenocarcinomas of the endometrium diagnosed between 2010 and 2012 and recorded in the National Cancer Database. The risk of nodal metastasis associated with LVSI stratified by grade and stage is reported. The association of LVSI and survival was examined using Kaplan-Meier analyses and Cox proportional hazards models. We identified 25,907 patients, including 3928 (15.2%) with LVSI. Among patients with LVSI, 21.0% had positive lymph nodes, compared to 2.1% in patients without LVSI (P<0.0001). In analyses stratified by stage and grade, LVSI was associated with increased risks of LN metastasis by a magnitude of 3 to over 10-fold. In a multivariable model controlling for clinical and demographic characteristics, the risk ratio of nodal disease with LVSI was 9.29 (95% CI, 7.29-11.84) for T1A tumors and 4.64 (95% CI 3.99-5.39) for T1B...Continue Reading

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Citations

Mar 15, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ellen CusanoYuhui Xu
May 31, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mikel Gorostidi PulgarPablo Padilla Iserte
Jun 7, 2019·American Journal of Clinical Oncology·Dustin BootheDavid K Gaffney
Feb 12, 2019·Journal of Gynecologic Oncology·Mehmet Ali VardarGulsah Seydaoglu
Apr 30, 2019·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Mehmet M MeydanliYaprak Engin-Ustun
Aug 10, 2020·Revista colombiana de obstetricia y ginecología·Robinson Segundo Fernández-MercadoÉdgar Navarro-Lechuga
Jan 23, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ali AyhanMehmet Mutlu Meydanli
Feb 14, 2019·Der Pathologe·L-C HornUNKNOWN Kommission zur Erstellung der S3-Leitlinie „Diagnostik, Therapie und Nachsorge der Patientinnen mit Endometriumkarzinom“
Jul 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mikel Gorostidi PulgarPablo Padilla Iserte
Oct 7, 2020·Gynecologic Oncology·Aaron M PraissJason D Wright
Mar 3, 2021·Journal of Gynecologic Oncology·Fiorella E Reyes-BaezAndrea Mariani
Mar 14, 2021·Surgical Oncology·M Reyes Oliver-PerezAlvaro Tejerizo-Garcia

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