Magnolol administration in normotensive young spontaneously hypertensive rats postpones the development of hypertension: role of increased PPAR gamma, reduced TRB3 and resultant alleviative vascular insulin resistance

PloS One
Xiangyan LiangHaifeng Zhang

Abstract

Patients with prehypertension are more likely to progress to manifest hypertension than those with optimal or normal blood pressure. However, the mechanisms underlying the development from prehypertension to hypertension still remain largely elusive and the drugs for antihypertensive treatment in prehypertension are absent. Here we determined the effects of magnolol (MAG) on blood pressure and aortic vasodilatation to insulin, and investigated the underlying mechanisms. Four-week-old male spontaneous hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto (WKY) control rats were used. Our results shown that treatment of young SHRs with MAG (100 mg/kg/day, o.g.) for 3 weeks decreased blood pressure, improved insulin-induced aorta vasodilation, restored Akt and eNOS activation stimulated by insulin, and increased PPARγ and decreased TRB3 expressions. In cultured human umbilical vein endothelial cells (HUVECs), MAG incubation increased PPARγ, decreased TRB3 expressions, and restored insulin-induced phosphorylated Akt and eNOS levels and NO production, which was blocked by both PPARγ antagonist and siRNA targeting PPARγ. Improved insulin signaling in HUVECs by MAG was abolished by upregulating TRB3 expression. In conclusi...Continue Reading

References

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Citations

Dec 30, 2015·International Journal of Molecular Sciences·You-Lin TainJulie Y H Chan
Jul 21, 2015·Journal of the American Society of Hypertension : JASH·Chenyu LiXiangbo Chi
Dec 21, 2017·Scientific Reports·Hanna KukThomas Korff
Jun 25, 2020·Biomolecules & Therapeutics·Yujia HanMinsoo Noh
Jun 14, 2018·International Journal of Molecular Sciences·You-Lin Tain, Chien-Ning Hsu
Jan 28, 2021·International Journal of Molecular Sciences·Ana Lago-FernandezPaula Morales
Sep 29, 2021·Journal of Agricultural and Food Chemistry·Hu LiYin-Fang Yan

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Methods Mentioned

BETA
transfection
antisense oligonucleotide

Software Mentioned

Lab Image
Chariot

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