Magnolol and honokiol regulate the calcium-activated potassium channels signaling pathway in Enterotoxigenic Escherichia coli-induced diarrhea mice

European Journal of Pharmacology
Yanli DengJinghe Kang

Abstract

To explore the regulatory mechanisms of magnolol and honokiol on calcium-activated potassium channels signaling pathway in Enterotoxigenic Escherichia coli (ETEC)-induced diarrhea mice, the concentrations of serum chloride ion (Cl(-)), sodium ion (Na(+)), potassium ion (K(+)) and calcium ion (Ca(2+)) were measured. Additionally, the mRNA expressions of calmodulin 1 (CaM), calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) and beta subunit (CaMKIIβ), ryanodine receptor 1, inositol 1,4,5-trisphosphate receptors (IP3 receptors), protein kinases C (PKC), potassium intermediate/small conductance calcium-activated channels (SK) and potassium large conductance calcium-activated channels(BK)were determined. A diarrhea mouse model was established using ETEC suspensions (3.29×10(9)CFU/ml) at a dosage of 0.02ml/g live body weight (BW). Magnolol or honokiol was intragastrically administered at dosages of 100 (M100 or H100), 300 (M300 or H300) and 500 (M500 or H500) mg/kg BW according to a 3×3 factorial arrangement. Magnolol and honokiol increased the Cl(-) and K(+) concentrations, further, upregulated the CaM, BKα1 and BKβ3 mRNA levels but downregulated the IP3 receptors 1, PKC, SK1, SK2, SK3, SK4 and BKβ4 mRNA expressi...Continue Reading

References

Mar 27, 2001·Phytotherapy Research : PTR·K Y HoC C Lin
Jan 5, 2002·Physiological Reviews·Karl Kunzelmann, Marcus Mall
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 19, 2003·European Journal of Pharmacology·Haifeng ZhaiYoshiyasu Fukuyama
Feb 18, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Scott A BarmanRichard E White
Mar 23, 2004·Journal of Cellular Biochemistry·Shih-Horng HuangSeu-Mei Wang
Sep 11, 2007·Life Sciences·Yi-Ruu LinMing-Huan Chan
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qiang LiuZhao-Wen Wang
Jul 26, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marion SimonPhilippe Marteau
Mar 13, 2009·Archives of Pharmacal Research·Yung-Hsiang ChenMing-Tsung Lai
Nov 4, 2009·Microbes and Infection·James M FleckensteinHans Steinsland
Apr 13, 2010·Pflügers Archiv : European journal of physiology·Gillian EdwardsArthur H Weston
Oct 21, 2010·Physiological Reviews·Henrike BerkefeldUwe Schulte
Feb 11, 2011·Journal of Neurophysiology·Ingrid van Welie, Sascha du Lac
Feb 18, 2011·Gut Microbes·Kim Hodges, Ravinder Gill
Jan 30, 2013·Cell Calcium·Angelo O RosaMartin Morad

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Citations

Jul 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ling ZhaoZhao-Xiang Bian
Jun 27, 2019·BioMed Research International·Jianhong ZhangLonghuo Wu
Nov 6, 2018·Frontiers in Microbiology·Hucong WuGuoqiang Zhu
Oct 22, 2019·Frontiers in Pharmacology·Joaquim Olivés, Jordi Mestres
Mar 8, 2021·BMC Complementary Medicine and Therapies·Xu SongZhongqiong Yin
Apr 6, 2021·Frontiers in Pharmacology·Yiping LinYing Song
Aug 8, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Abdur RaufMohammad Ali Shariati

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