Abstract
Silent information regulator 1 (SIRT1), a histone deacetylase, plays a protective role in ischemic brain injury. Previous studies have shown that magnolol has a beneficial effect on ischemic stroke; however, the role of SIRT1 in the protective effect of magnolol against cerebral ischemia has not been investigated. We used a middle cerebral artery occlusion model of stroke in rats. Before stroke induction, the rats received intraperitoneal injections of magnolol with or without the SIRT1 inhibitor, EX527. Brain water content, neurological score, and infarct volume were measured. Moreover, the levels of the proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured. Western blot analysis was performed to detect Ac-FOXO1, SIRT1, bax, and Bcl-2 expression. Magnolol exerted a beneficial effect on cerebral ischemia, as indicated by reduced brain edema, decreased infarct volume, and improved neurological score. Magnolol had an anti-inflammatory effect mediated by a decrease in the expression of IL-1β and TNF-α in the brain tissue. Additionally, magnolol down-regulated bax and Ac-FOXO1 expression and up-regulated Bcl-2 and SIRT1 expression. This effect of magnolol was abolished by EX527 treatment...Continue Reading
References
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jan 1, 1993·Stroke; a Journal of Cerebral Circulation·H P AdamsE E Marsh
Jan 1, 1993·Stroke; a Journal of Cerebral Circulation·T N LinC Y Hsu
Dec 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·K G TannerJ M Denu
Oct 1, 1956·Journal of Consulting Psychology·L H BECKI SARASON
Jul 25, 2007·Progress in Brain Research·Chen-Kuei ChangMao-Tsun Lin
Apr 21, 2009·Life Sciences·Sun-Sil ChoiJe-Tae Woo
Jan 19, 2010·Genes & Development·Anne Norris, Jef D Boeke
Apr 8, 2010·Molecular Cancer Therapeutics·Barrie PeckEric W-F Lam
Nov 10, 2010·Circulation·Chiao-Po HsuJunichi Sadoshima
Nov 30, 2010·Radiologic Clinics of North America·Mara M Kunst, Pamela W Schaefer
Jan 18, 2011·The Journal of Biological Chemistry·Mehdi ShakibaeiAli Mobasheri
Jun 15, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Glen C Jickling, Frank R Sharp
Jul 13, 2011·The Journal of Physiology·Anthony J DonatoDouglas R Seals
Jul 4, 2012·Biochemical Pharmacology·Ching-Yu Shih, Tz-Chong Chou
Dec 22, 2012·Schizophrenia Bulletin·Victor PeraltaManuel J Cuesta
Jul 20, 2014·Toxicology and Applied Pharmacology·Jiann-Hwa ChenTung-Hu Tsai
Feb 21, 2016·Journal of Cellular Physiology·Sara FranceschelliLorenza Speranza
Citations
Jul 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ling ZhaoZhao-Xiang Bian
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chengli LingJianxin Wang
Feb 6, 2018·Neurochemical Research·Yucong PengGao Chen
Aug 30, 2017·Cell Biology International·Chun-Yang WangChao Zhang
Sep 6, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Pinggang DingJianming Ju
Jul 6, 2020·Aging·Zhi-Gang MeiHua-Jun Zhou
Oct 1, 2020·The Journal of International Medical Research·Chengli LingYuhong Wang
Dec 7, 2018·Frontiers in Neuroscience·Jun-Fang ZhangYun-Cheng Wu
Mar 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhekang ChengJianxin Wang
Aug 28, 2020·Frontiers in Neuroscience·Qianjie YangAnwen Shao
Dec 31, 2019·Neural Plasticity·Xiangli YanLisheng Wang
May 5, 2020·Metabolic Brain Disease·Huiyuan ZhangCong Feng
Jun 27, 2019·BioMed Research International·Jianhong ZhangLonghuo Wu
Feb 13, 2018·The Journal of Pharmacy and Pharmacology·Hongxue ShenGuohui Liang
Oct 6, 2020·Oxidative Medicine and Cellular Longevity·Fangzhou Jiao, Zuojiong Gong
Aug 15, 2018·International Journal of Molecular Sciences·Abhishek Manoj RanawareAjaikumar B Kunnumakkara
Dec 5, 2020·Journal of Ethnopharmacology·Tingting LouXiangyan Li
Jan 27, 2021·Molecular Neurobiology·Anderson Velasque CatarinaFernanda Bordignon Nunes
Feb 10, 2021·Journal of Inflammation·Wei WangRui Chen
Mar 2, 2021·Brain Research Bulletin·Juyun MaSuhua Qi
Apr 6, 2021·Frontiers in Pharmacology·Yiping LinYing Song
Apr 9, 2018·International Immunopharmacology·Jie ChengQing Liu
May 5, 2021·Journal of Biochemical and Molecular Toxicology·Muhammad A E SaadMuhammad Al-Shorbagy
May 4, 2021·Frontiers in Pharmacology·Yunxia LuoJiangang Shen
Jul 21, 2021·Neurochemistry International·Pooja KaushikSuhel Parvez
Aug 29, 2021·Plants·Hyun-Woo KimWon-Keun Oh
Sep 30, 2021·Journal of Leukocyte Biology·Duobin ZhangMaolin Hao
Oct 28, 2021·Journal of Natural Medicines·Gemin ZhuRui Zhao