Magnolol attenuates the inflammation and apoptosis through the activation of SIRT1 in experimental stroke rats

Pharmacological Reports : PR
Dong-Quan KouYin-Hui Huang

Abstract

Silent information regulator 1 (SIRT1), a histone deacetylase, plays a protective role in ischemic brain injury. Previous studies have shown that magnolol has a beneficial effect on ischemic stroke; however, the role of SIRT1 in the protective effect of magnolol against cerebral ischemia has not been investigated. We used a middle cerebral artery occlusion model of stroke in rats. Before stroke induction, the rats received intraperitoneal injections of magnolol with or without the SIRT1 inhibitor, EX527. Brain water content, neurological score, and infarct volume were measured. Moreover, the levels of the proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured. Western blot analysis was performed to detect Ac-FOXO1, SIRT1, bax, and Bcl-2 expression. Magnolol exerted a beneficial effect on cerebral ischemia, as indicated by reduced brain edema, decreased infarct volume, and improved neurological score. Magnolol had an anti-inflammatory effect mediated by a decrease in the expression of IL-1β and TNF-α in the brain tissue. Additionally, magnolol down-regulated bax and Ac-FOXO1 expression and up-regulated Bcl-2 and SIRT1 expression. This effect of magnolol was abolished by EX527 treatment...Continue Reading

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Citations

Jul 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ling ZhaoZhao-Xiang Bian
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chengli LingJianxin Wang
Sep 6, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Pinggang DingJianming Ju
Oct 1, 2020·The Journal of International Medical Research·Chengli LingYuhong Wang
Dec 7, 2018·Frontiers in Neuroscience·Jun-Fang ZhangYun-Cheng Wu
Mar 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhekang ChengJianxin Wang
Jun 27, 2019·BioMed Research International·Jianhong ZhangLonghuo Wu
Feb 13, 2018·The Journal of Pharmacy and Pharmacology·Hongxue ShenGuohui Liang
Oct 6, 2020·Oxidative Medicine and Cellular Longevity·Fangzhou Jiao, Zuojiong Gong
Aug 15, 2018·International Journal of Molecular Sciences·Abhishek Manoj RanawareAjaikumar B Kunnumakkara
Dec 5, 2020·Journal of Ethnopharmacology·Tingting LouXiangyan Li
Jan 27, 2021·Molecular Neurobiology·Anderson Velasque CatarinaFernanda Bordignon Nunes
Apr 6, 2021·Frontiers in Pharmacology·Yiping LinYing Song
May 5, 2021·Journal of Biochemical and Molecular Toxicology·Muhammad A E SaadMuhammad Al-Shorbagy

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