Magnolol Inhibits Osteoclast Differentiation via Suppression of RANKL Expression

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Youn-Hwan HwangHyunil Ha

Abstract

Magnolol, a compound from the traditional Korean herb Magnolia sp., has been exhaustively investigated as a therapeutic agent against several diseases including systemic and local inflammation. We examined the effects of magnolol on osteoclastic differentiation associated with inflammation. Magnolol markedly reduced interleukin (IL)-1-induced osteoclast formation in co-cultures of murine osteoblasts and bone marrow cells, whereas it had no effect on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation in bone marrow macrophage cultures. In osteoblasts, magnolol markedly inhibited both the up-regulation of RANKL expression and the production of prostaglandin E₂ (PGE₂) in response to IL-1 treatment. Addition of exogenous PGE₂ reversed the inhibitory effects of magnolol on IL-1-induced RANKL expression in osteoblasts and osteoclast formation in co-cultures. Magnolol inhibited IL-1-induced PGE₂ production, at least in part by suppressing cyclooxygenase-2 (COX-2) expression. Taken together, these results demonstrate that magnolol inhibits IL-1-induced RANKL expression in osteoblasts through suppression of COX-2 expression and PGE₂ production, resulting in inhibition of osteoclast differentiation in co-...Continue Reading

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Citations

Aug 28, 2020·Journal of the Science of Food and Agriculture·Cheng-Liang XieDong H Lee
Apr 6, 2021·Frontiers in Pharmacology·Yiping LinYing Song
Apr 26, 2021·Trends in Endocrinology and Metabolism : TEM·Daniele BellaviaGianluca Giavaresi

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR
electrophoresis

Software Mentioned

Prism

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