Mahuang Fuzi Xixin Decoction Ameliorates Allergic Rhinitis in Rats by Regulating the Gut Microbiota and Th17/Treg Balance.

Journal of Immunology Research
Xiao LiangXiao-mei Tan

Abstract

Mahuang Fuzi Xixin Decoction (MFXD), a Chinese traditional herbal formulation, has been used to treat allergic rhinitis (AR) in China for centuries. However, the mechanism underlying its effect on AR is unclear. This study investigated the mechanism underlying the therapeutic effects of MFXD on AR. Ovalbumin-induced AR rat models were established, which were then treated with MFXD for 14 days. Symptom scores of AR were calculated. The structure of the gut microbiota was analyzed by 16S rRNA gene sequencing and qPCR. Short-chain fatty acid (SCFA) content in rat stool and serum was determined by GC-MS. Inflammatory and immunological responses were assessed by histopathology, ELISA, flow cytometry, and western blotting. Our study demonstrated that MFXD reduced the symptom scores of AR and serum IgE and histamine levels. MFXD treatment restored the diversity of the gut microbiota: it increased the abundance of Firmicutes and Bacteroidetes and decreased the abundance of Proteobacteria and Cyanobacteria. MFXD treatment also increased SCFA content, including that of acetate, propionate, and butyrate. Additionally, MFXD administration downregulated the number of Th17 cells and the levels of the Th17-related cytokines IL-17 and RORγt. B...Continue Reading

References

Dec 27, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nivenka P JayasekeraK Rajakulasingam
Apr 17, 2007·Pharmacology & Therapeutics·Yousuf M Al Suleimani, Michael J A Walker
May 31, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K IvoryC Nicoletti
Jun 8, 2012·Science·Jeremy K NicholsonSven Pettersson
Sep 18, 2012·Allergy and Asthma Proceedings·Eli O MeltzerMark A Wingertzahn
Apr 4, 2013·Current Opinion in Allergy and Clinical Immunology·Ola StorrøKnut Rudi
Jan 7, 2014·Nature Medicine·Aurélien TrompetteBenjamin J Marsland
Dec 30, 2014·Nutrients·Michael A Conlon, Anthony R Bird
Jul 15, 2015·International Journal of Pediatric Otorhinolaryngology·Kun NiXiaoyan Li
Sep 5, 2015·Gut·Julian R MarchesiAilsa Hart
Jul 8, 2016·Nature·Kenya Honda, Dan R Littman
Jul 31, 2016·Genes & Development·Maayan LevyEran Elinav
Dec 9, 2016·Environmental Microbiology·Petra Louis, Harry J Flint
Jan 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yu JingShao-Qing Cai
Aug 24, 2017·International Journal of Biological Macromolecules·Shanshan LiangQiuhong Wang
Feb 14, 2018·Advances in Nutrition·Hu LiuXi Ma
Apr 11, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Juan ZhongGang Li
Jul 23, 2018·Irish Journal of Medical Science·Marlene M SpethAhmad R Sedaghat
Jan 21, 2019·Allergy, Asthma & Immunology Research·Yuan Zhang, Luo Zhang
Mar 5, 2019·The Journal of Clinical Investigation·Andrea M Kemter, Cathryn R Nagler
Apr 13, 2019·Mucosal Immunology·Anh Thu Dang, Benjamin J Marsland
Jun 30, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wei ZhangLiyun Shi
Aug 23, 2019·Immunity·Sean P SpencerJustin L Sonnenburg
Jan 14, 2020·International Immunopharmacology·Bing Wu, Yisong Wan

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
PCR
flow cytometry
protein assay
PCA

Software Mentioned

ImageJ
UPARSE
FLASH
QIIME

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here