Main ethanol metabolizing alcohol dehydrogenases (ADH I and ADH IV): biochemical functions and the physiological manifestation

FEBS Letters
I P AshmarinV N Prosorovsky

Abstract

The range of the biochemical reactions which can be catalyzed by ADH I and ADH IV is extremely wide. The most characterized functions of these enzymes are protection against excess endogenous acetaldehyde, products of lipid peroxidation, exogenous alcohols and some xenobiotics. It was found also that ADH I and ADH IV are important members of the enzyme system synthesizing retinoic acid (especially during embryogenesis). They can oxidize some steroids and participate in bioamine and prostaglandin metabolism but so far the extent of their contribution to the latter processes is under discussion. Recent data suggest a correlation between the activity of ADH I in some organs and fine physiological processes including behavior regulation and craving for alcohol in albino rats.

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Citations

Jul 20, 2002·Reproductive Toxicology·Ujjwal Kumar Rout, D Randall Armant
Jul 30, 2014·Alcohol·Napoleon WaszkiewiczSławomir Dariusz Szajda
Jun 3, 2011·Journal of Veterinary Emergency and Critical Care·Naglaa Abdel Megid GomaaGerald Fritz Schusser
May 25, 2006·Journal of Clinical Laboratory Analysis·Wojciech JelskiMaciej Szmitkowski
Jul 25, 2021·Cancers·Francisco D Rodriguez, Rafael Coveñas
Dec 28, 2021·Journal of Proteomics·Emily L O'ReillyAlison Ridyard

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