Main pulmonary artery area limits exercise capacity in patients long-term after arterial switch operation

The Journal of Thoracic and Cardiovascular Surgery
Vivan J M BaggenJohannes M P J Breur

Abstract

Despite excellent survival in patients after the arterial switch operation, reintervention is frequently required and exercise capacity is decreased in a substantial number of patients. This study relates right-sided imaging features in patients long-term after the arterial switch operation to exercise capacity and ventilatory efficiency to investigate which lesions are functionally important. Patients operated in the UMC Utrecht, the Netherlands (1976-2001) and healthy controls underwent cardiac magnetic resonance imaging and cardiopulmonary exercise testing within 1 week. We measured main, left, and right pulmonary artery cross-sectional areas, pulmonary blood flow distribution, peak oxygen uptake, and minute ventilation relative to carbon dioxide elimination. A total of 71 patients (median age, 20 [12-35] years, 73% were male) and 21 healthy controls (median age, 26 [21-35] years, 48% were male) were included. Main, left, and right pulmonary artery areas were decreased compared with controls (190 vs 269 mm(2)/m(2), 59 vs 157 mm(2)/m(2), 98 vs 139 mm(2)/m(2), respectively, all P < .001); however, pulmonary blood flow distribution was comparable (P = .722). Peak oxygen uptake and minute ventilation relative to carbon dioxide e...Continue Reading

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Citations

Mar 28, 2016·The Journal of Thoracic and Cardiovascular Surgery·Petros V Anagnostopoulos
Oct 2, 2015·The Journal of Thoracic and Cardiovascular Surgery·Ralph S Mosca
Sep 14, 2016·Clinical Imaging·Cheng Ting LinElliot K Fishman
Sep 10, 2019·World Journal for Pediatric & Congenital Heart Surgery·Yue-Hin LokeLaura J Olivieri
Feb 3, 2021·Pediatric Cardiology·Covadonga Terol Espinosa de Los MonterosArend D J Ten Harkel
Sep 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Alfred Hager

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