Maintaining cell identity through global control of genomic organization

Immunity
Gioacchino Natoli

Abstract

Cell differentiation entails early lineage choices leading to the activation, and the subsequent maintenance, of the gene expression program characteristic of each cell type. Alternative lineage choices involve the activation of different regulatory and coding regions of the genome, a process instructed by lineage-determining transcription factors, and at least in part mediated by the deposition of chromatin marks that modify functionality and accessibility of the underlying genome. According to classic epigenetics, subsequent maintenance of chromatin marks across mitoses and in spite of environmental perturbations occurs largely through autonomous and unsupervised mechanisms. However, paradigmatic genetic and biochemical studies in immune system and hematopoietic cells strongly point to the concept that both induction and maintenance of the differentiated state require constant supervision by lineage-determining transcription factors, which may act to globally organize the genome in both the one- and the three-dimensional space.

References

May 17, 1994·Biochimica Et Biophysica Acta·B BaumgärtnerR Knippers
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·S L NuttM Busslinger
Aug 11, 2001·Science·T Jenuwein, C D Allis
Jul 16, 2003·Molecular and Cellular Biology·Robert A Waterland, Randy L Jirtle
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Charles D LairdReinhard Stöger
May 6, 2004·Molecular Neurobiology·Kim A Heidenreich, Daniel A Linseman
May 28, 2004·Cell·Huafeng XieThomas Graf
Jan 29, 2005·The EMBO Journal·Joost H A MartensThomas Jenuwein
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrei KuzmichevDanny Reinberg
May 10, 2005·Nature·Charalampos G SpilianakisRichard A Flavell
Jul 1, 2005·Nature·Tae Hoon KimBing Ren
Jan 13, 2006·Trends in Biochemical Sciences·Robert J Klose, Adrian P Bird
Apr 29, 2006·Nature Genetics·Piero CarninciYoshihide Hayashizaki
Jun 14, 2006·Genome Research·Shyam PrabhakarLen A Pennacchio
Oct 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tae-Young RohKeji Zhao
Jan 30, 2007·Nature Reviews. Immunology·Frank Rosenbauer, Daniel G Tenen
Feb 27, 2007·Cell·Bradley E BernsteinEric S Lander
Feb 27, 2007·Cell·Tony Kouzarides
Feb 27, 2007·Cell·Bernd SchuettengruberGiacomo Cavalli
Apr 19, 2007·Nature Immunology·César CobaledaMeinrad Busslinger
Jun 2, 2007·Science·David S JohnsonBarbara Wold
Jul 12, 2007·The Journal of Biological Chemistry·Monika LichtingerMichael Rehli
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jian XuStephen T Smale

❮ Previous
Next ❯

Citations

Dec 7, 2010·Transgenic Research·Junko AsamiTakayoshi Inoue
Oct 15, 2011·Nature Biotechnology·Thomas Vierbuchen, Marius Wernig
Jul 21, 2011·Nature Immunology·Stephen T Smale
Sep 22, 2011·Nature Immunology·Benjamin L KidderKeji Zhao
Jul 23, 2013·Nature Immunology·Silvia Monticelli, Gioacchino Natoli
Mar 26, 2011·Nature Reviews. Immunology·John J O'SheaYuka Kanno
Oct 26, 2011·Nature Reviews. Immunology·Toby Lawrence, Gioacchino Natoli
Mar 15, 2013·Nature Reviews. Molecular Cell Biology·Julia LadewigOliver Brüstle
Jul 3, 2013·Briefings in Functional Genomics·Marta Simonatto, Gioacchino Natoli
May 8, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Serena Ghisletti, Gioacchino Natoli
Dec 14, 2011·Genes & Development·Shannon E MullicanMitchell A Lazar
Jan 20, 2011·Genes & Development·Gioacchino NatoliIros Barozzi
Sep 28, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William P AccomandoKarl T Kelsey
May 10, 2012·BMC Bioinformatics·Eugene Andres HousemanKarl T Kelsey
Jun 3, 2011·World Journal of Gastroenterology : WJG·Pranoti Mandrekar
Feb 22, 2014·Annual Review of Immunology·Stephen T SmaleGioacchino Natoli
May 21, 2014·Nature Immunology·Kerri A Mowen, Michael David
Mar 29, 2014·Cellular and Molecular Life Sciences : CMLS·Moonmoon DebSamir Kumar Patra
Aug 22, 2012·Annual Review of Genetics·Gioacchino Natoli, Jean-Christophe Andrau
Sep 22, 2012·Comparative and Functional Genomics·Bruna Barneda-ZahoneroMaribel Parra
Aug 3, 2013·Current Opinion in Cell Biology·Renato Ostuni, Gioacchino Natoli
Jul 31, 2013·Expert Review of Molecular Diagnostics·Maria M Esterhuyse, Stefan He Kaufmann
Jul 21, 2015·Genes·Virlana M ShchukaJennifer A Mitchell
Mar 23, 2013·Expert Opinion on Biological Therapy·Xiaoyan SunLaura Chalmers
Aug 31, 2014·Journal of Molecular Biology·Jörg SchönheitFrank Rosenbauer
Dec 12, 2012·Trends in Immunology·Lionel B Ivashkiv
Aug 8, 2012·Current Opinion in Genetics & Development·Kenjiro Adachi, Hans R Schöler
Apr 3, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wim Vanden Berghe
Nov 18, 2015·Reviews in Medical Virology·Liane Dupont, Matthew B Reeves
Nov 10, 2010·Tissue Antigens·J L Fernández-MoreraM F Fraga
Aug 19, 2011·The EMBO Journal·Aleksandra PekowskaSalvatore Spicuglia
Feb 15, 2013·Immunological Reviews·Golnaz VahediKiyoshi Hirahara
Sep 29, 2011·European Journal of Immunology·Renato Ostuni, Gioacchino Natoli
Dec 3, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Robin Andersson
Aug 16, 2014·Immunological Reviews·Deborah R Winter, Ido Amit
Apr 1, 2014·Biochimica Et Biophysica Acta·Monica SoldiTiziana Bonaldi
Apr 7, 2016·Seminars in Immunology·Joachim L Schultze, Susanne V Schmidt
Aug 19, 2015·Trends in Immunology·Steven WitteGolnaz Vahedi
Apr 14, 2012·Current Opinion in Cell Biology·Daniel HebenstreitSarah A Teichmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.