Maintaining Concentration of Ribavirin in Cerebrospinal Fluid by a New Dosage Method; 3 Cases of Subacute Sclerosing Panencephalitis Treated Using a Subcutaneous Continuous Infusion Pump

The Pediatric Infectious Disease Journal
Kyohei MiyazakiMitsuaki Hosoya

Abstract

Subacute sclerosing panencephalitis (SSPE) is a slow virus infectious disease resulting from persistent infection with mutant measles virus. At present, there is no effective treatment for SSPE. Interferon-α and inosine pranobex have both been used for the treatment of SSPE, and partial success has been reported for the antiviral drug, ribavirin (RBV). The standardization of dosage method is necessary to carry out treatment with RBV more safely and effectively. In this study, RBV concentrations in cerebrospinal fluid (CSF) were monitored during the intraventricular administration using a subcutaneous continuous infusion pump. Three patients with new-onset SSPE were treated with RBV using a subcutaneous continuous infusion pump. On days 3-10 after the start of RBV infusion, CSFs were obtained by lumbar tap, and the concentration of RBV in the CSF was measured using high-performance liquid chromatography. RBV concentration increased in a dose-dependent manner in all 3 patients, and the target concentration could be generally maintained without any severe side effects. We observed that the clinical symptoms were temporarily relieved in each case. In the 2 cases for whom treatment is continuing, the patients remain in stage III, wh...Continue Reading

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Citations

Nov 7, 2019·Viruses·Marion FerrenCyrille Mathieu
Aug 31, 2020·Japanese Journal of Infectious Diseases·Koichi HashimotoMitsuaki Hosoya
Jan 27, 2019·Developmental Medicine and Child Neurology·Mohammed MekkiJo M Wilmshurst
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Koichi Hashimoto, Mitsuaki Hosoya

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