Maintaining monodispersity in a microbubble population formed by flow-focusing.

Langmuir : the ACS Journal of Surfaces and Colloids
Esra TaluMarjorie L Longo

Abstract

The dynamic processes impacting the size distributions of lipid-encapsulated microbubbles formed by flow-focusing were observed by video optical microscopy. Parameters studied included the filling gas, gas saturating the surrounding solution, and microbubble size (initial size 2-12 microm) to simulate typical laboratory conditions. Typically, dissolution or growth, followed by Ostwald ripening at a collection cover glass, were observed and quantified. However, in the case of small nitrogen-filled microbubbles surrounded by an air-saturated solution, Ostwald ripening was avoided for at least 9 h. These bubbles had a final size distribution of 1.5 +/- 0.1 microm. This work suggests that lipid-encapsulated microbubbles formed by flow-focusing should be given sufficient time to reach a terminal size before coming into contact with each other. These long-lived mondisperse microbubbles should be of interest in ultrasound contrast agents, microfabrication, food, and research applications.

References

Jun 6, 2000·Advanced Drug Delivery Reviews·A L Klibanov
Jan 22, 2002·Physical Review Letters·A M Gañán-Calvo, J M Gordillo
Apr 28, 2004·Advanced Drug Delivery Reviews·Evan C UngerReena Zutshi
May 26, 2004·Cardiology Clinics·Flordeliza S VillanuevaJagat Narula
Jul 21, 2004·Colloids and Surfaces. B, Biointerfaces·Mark A BordenMarjorie L Longo
Apr 19, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Mark A BordenKatherine W Ferrara
Nov 1, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Esra TaluMarjorie L Longo
Feb 14, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Atsushi HozumiTetsuya Kameyama

❮ Previous
Next ❯

Citations

May 13, 2009·Medical & Biological Engineering & Computing·Eleanor Stride, Mohan Edirisinghe
Jun 26, 2009·Accounts of Chemical Research·Katherine W FerraraHua Zhang
Jul 26, 2012·Journal of the American Chemical Society·Elizabeth HuynhGang Zheng
Jan 31, 2008·Lab on a Chip·Shia-Yen TehAbraham P Lee
Mar 25, 2011·Lab on a Chip·Elena Castro-HernándezJosé M Gordillo
Mar 22, 2014·Lab on a Chip·Tim Segers, Michel Versluis
Aug 27, 2013·Methods : a Companion to Methods in Enzymology·Guixin ShiDmitri Simberg
Jan 29, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Roger Shih, Abraham P Lee
Mar 5, 2013·Ultrasound in Medicine & Biology·Chung-Hsin Wang, Chih-Kuang Yeh
Sep 11, 2012·Advances in Colloid and Interface Science·James J Kwan, Mark A Borden
May 15, 2012·Ultrasound in Medicine & Biology·Peter J A FrinkingFrançois Tranquart
Sep 20, 2011·Ultrasound in Medicine & Biology·Stanley FokongJessica Gätjens
Aug 12, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·E A FerranteK Ley
Mar 11, 2009·European Journal of Radiology·Marcel R BöhmerOliver C Steinbach
Oct 28, 2008·Journal of Colloid and Interface Science·Jameel A FeshitanMark A Borden
May 21, 2009·Biotechnology Progress·Kanaka HettiarachchiPaul A Dayton
Mar 24, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Tim SegersMichel Versluis
Mar 27, 2016·Medical & Biological Engineering & Computing·Hangyu LinChuanpin Chen
Aug 1, 2015·Lab on a Chip·Maarten P KokMichel Versluis
May 7, 2013·Ultrasound in Medicine & Biology·Adam J DixonJohn A Hossack
Oct 31, 2016·The Journal of the Acoustical Society of America·Tim SegersMichel Versluis
Mar 14, 2017·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Tom van RooijKlazina Kooiman
Oct 1, 2014·Journal of Medical Ultrasonics·Zhonghua TengJianping Bin
Jan 6, 2021·Physical and Engineering Sciences in Medicine·Hussain AlsadiqMartin Veidt
Oct 16, 2013·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·M A HerradaJ M Montanero
Apr 7, 2021·The Review of Scientific Instruments·Benjamin van ElburgGuillaume Lajoinie
Jan 27, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Simona RossiMarie Pierre Krafft
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Monica M Lozano, Marjorie L Longo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.