Maintaining order: COG complex controls Golgi trafficking, processing, and sorting.

FEBS Letters
Jessica B BlackburnVladimir V Lupashin

Abstract

The conserved oligomeric Golgi (COG) complex, a multisubunit tethering complex of the CATCHR (complexes associated with tethering containing helical rods) family, controls membrane trafficking and ensures Golgi homeostasis by orchestrating retrograde vesicle targeting within the Golgi. In humans, COG defects lead to severe multisystemic diseases known as COG-congenital disorders of glycosylation (COG-CDG). The COG complex both physically and functionally interacts with all classes of molecules maintaining intra-Golgi trafficking, namely SNAREs, SNARE-interacting proteins, Rabs, coiled-coil tethers, and vesicular coats. Here, we review our current knowledge of COG-related trafficking and glycosylation defects in humans and model organisms, and analyze possible scenarios for the molecular mechanism of the COG orchestrated vesicle targeting.

References

Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D M Kingsley, M Krieger
Jun 12, 1998·The Journal of Cell Biology·S M VanRheenenM G Waters
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·D FasshauerR Jahn
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J E ChattertonM Krieger
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y A Chen, R H Scheller
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y Hua, R H Scheller
May 15, 2002·Molecular Biology of the Cell·Rachna J RamChris A Kaiser
Oct 11, 2002·Neurochemical Research·Hugo J F MaccioniJosé Luis Daniotti
May 3, 2003·Nature Reviews. Molecular Cell Biology·Juan S Bonifacino, Jennifer Lippincott-Schwartz
Aug 2, 2003·Molecular Membrane Biology·Rainer Duden
Aug 14, 2003·Biochimica Et Biophysica Acta·Alison K Gillingham, Sean Munro
Oct 4, 2003·The Journal of Biological Chemistry·Serge MoskalenkoMichael A White
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fabienne PaumetJames E Rothman
Apr 27, 2004·Nature Medicine·Xiaohua WuHudson H Freeze
Feb 25, 2005·The Journal of Cell Biology·Sergey N Zolov, Vladimir V Lupashin
May 17, 2005·Biochimica Et Biophysica Acta·Wanjin Hong
Jun 4, 2005·The Journal of Biological Chemistry·Pierre FotsoVladimir V Lupashin
Jul 16, 2005·The Journal of Biological Chemistry·Daniel UngarFrederick M Hughson
Dec 13, 2005·American Journal of Physiology. Cell Physiology·Elizabeth Sztul, Vladimir Lupashin
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Melissa A EdelingDavid Owen
Mar 3, 2006·Molecular Biology of the Cell·Richard Steet, Stuart Kornfeld
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·François FoulquierGert Matthijs
Apr 25, 2006·Nature Reviews. Molecular Cell Biology·Crislyn D'Souza-Schorey, Philippe Chavrier
Jun 7, 2006·Nature Reviews. Genetics·Hudson H Freeze
Jul 22, 2006·Experimental Cell Research·Eliza VasileMonty Krieger
Aug 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Bianka L GrosshansPeter Novick
Aug 17, 2006·Nature Reviews. Molecular Cell Biology·Reinhard Jahn, Richard H Scheller
Jan 16, 2007·Cell·Jingshi ShenThomas J Melia

❮ Previous
Next ❯

Citations

Sep 10, 2019·FEBS Letters·Maria Antonietta De MatteisAlberto Luini
Dec 1, 2019·Genes·Sandra BrasilAnd Gonçalo Valadão
Jul 7, 2020·Biochemical Society Transactions·Richard T Timms, Itay Koren
Jul 8, 2020·International Journal of Molecular Sciences·Peter T A LindersGeert van den Bogaart
Sep 10, 2020·JIMD Reports·Katalin KomlosiJudith Fischer
Jul 24, 2020·Journal of Inherited Metabolic Disease·Walid HaouariArnaud Bruneel
Oct 10, 2020·Journal of Dental Research·S K WangJ C C Hu
Jul 31, 2020·Biochimica Et Biophysica Acta. General Subjects·Zinia D'SouzaVladimir V Lupashin
Sep 14, 2021·The EMBO Journal·Prathyush PothukuchiSeetharaman Parashuraman
Jun 27, 2021·Journal of Pediatric Gastroenterology and Nutrition·Rossella ColantuonoClaudia Mandato
Oct 5, 2021·Frontiers in Genetics·Farhana Taher SumyaVladimir Lupashin
Nov 17, 2021·FEBS Letters·Lukas A Huber
Dec 8, 2021·Biological Reviews of the Cambridge Philosophical Society·Charlotte ToustouMuriel Bardor

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
immunoprecipitation
GTPases
electron microscopy
fluorescence recovery after photobleaching

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.