Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report From the Children's Oncology Group Study ANBL0531

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clare J TwistSusan L Cohn

Abstract

The primary objective of the Children's Oncology Group study ANBL0531 (ClinicalTrials.gov identifier: NCT00499616) was to reduce therapy for subsets of patients with intermediate-risk neuroblastoma using a biology- and response-based algorithm to assign treatment duration while maintaining a 3-year overall survival (OS) of 95% or more for the entire cohort. Children younger than age 12 years with intermediate-risk stage 2A/2B or stage 3 tumors with favorable histology; infants younger than age 365 days with stage 3, 4 or 4S disease; and toddlers from 365 to younger than 547 days with favorable histology, hyperdiploid stage 4, or unfavorable histology stage 3 tumors were eligible. Patients with MYCN-amplified tumors were excluded. Patients were assigned to initially receive two (group 2), four (group 3), or eight (group 4) cycles of chemotherapy with or without surgery on the basis of prognostic markers, including allelic status of chromosomes 1p and 11q; ultimate duration of therapy was determined by overall response. Between 2007 and 2011, 404 evaluable patients were enrolled. Compared with legacy Children's Oncology Group studies, subsets of patients had a reduction in treatment. The 3-year event-free survival and OS rates we...Continue Reading

References

Apr 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A T LookG M Brodeur
Aug 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G M BrodeurF Hedborg
Apr 22, 1996·International Journal of Cancer. Journal International Du Cancer·G SchleiermacherJ Michon
Apr 28, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M MarisG M Brodeur
Jun 23, 2001·Neoplasia : an International Journal for Oncology Research·P MathewA T Look
Jul 6, 2001·Statistics in Medicine·A B Cantor
Aug 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rani E GeorgeA Thomas Look
Aug 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W B LondonS L Cohn
Aug 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary Lou SchmidtKatherine K Matthay
Nov 25, 2005·The New England Journal of Medicine·Edward F AttiyehUNKNOWN Children's Oncology Group
Jun 26, 2007·Lancet·John M MarisSusan L Cohn
Sep 4, 2008·British Journal of Cancer·B De BernardiUNKNOWN SIOP Europe Neuroblastoma Group
Dec 3, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan L CohnUNKNOWN INRG Task Force
Jan 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruno De BernardiAndrew D J Pearson
Jan 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Isabelle Janoueix-LeroseyOlivier Delattre
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gudrun SchleiermacherOlivier Delattre
Oct 1, 2010·The New England Journal of Medicine·David L BakerUNKNOWN Children’s Oncology Group
Oct 1, 2010·The New England Journal of Medicine·Alice L YuUNKNOWN Children's Oncology Group
Dec 22, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hervé RubieJean Michon
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Douglas R StrotherSusan L Cohn
Jan 22, 2013·Nature Genetics·Trevor J PughJohn M Maris
Sep 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andre OberthuerMatthias Fischer
Dec 2, 2014·Pediatric Clinics of North America·Meredith S Irwin, Julie R Park
Aug 26, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Navin R PintoSusan L Cohn
Nov 18, 2015·Current Opinion in Pediatrics·Rochelle Bagatell, Susan L Cohn
Nov 18, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clare J TwistJohn M Maris

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Citations

Apr 29, 2020·Pediatric Blood & Cancer·Michael P PerisaNilay Shah
Dec 15, 2020·Current Opinion in Pediatrics·Rosa Nguyen, Carol J Thiele
Feb 16, 2021·Clinics in Perinatology·Sarah G MitchellChristopher C Porter
Nov 7, 2020·Medicinal Research Reviews·Atif ZafarRuiwen Zhang
Oct 15, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martine J PiccartUNKNOWN BIG-NABCG Collaboration
May 1, 2021·International Journal of Environmental Research and Public Health·Asad UllahRobyn M Hatley
Jul 29, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Meredith S IrwinMichael D Hogarty
Aug 11, 2021·Surgical Pathology Clinics·Jonathan C Slack, Alanna J Church

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