Maintenance Adalimumab Concentrations Are Associated with Biochemical, Endoscopic, and Histologic Remission in Inflammatory Bowel Disease

Digestive Diseases and Sciences
Anna JuncadellaAdam S Cheifetz

Abstract

A treat-to-target therapeutic approach is emerging as the new standard of care for treating inflammatory bowel disease (IBD), Crohn's disease (CD), and ulcerative colitis (UC). We aimed to investigate the association of serum adalimumab concentrations during maintenance therapy with biochemical, endoscopic, and histologic remission in IBD. This retrospective multicenter study included consecutive IBD patients on adalimumab maintenance therapy who had a C-reactive protein (CRP) within 1 week and/or endoscopic evaluation within 12 weeks of therapeutic drug monitoring between July 2013 and December 2016. Biochemical remission was defined as a normal CRP (≤ 5 mg/L). Endoscopic remission was defined as the absence of any ulceration/erosion or a Rutgeerts score of ≤ i1 for patients with an ileocolonic resection for CD and a Mayo endoscopic score of ≤ 1 for UC. Histologic remission was defined as the absence of any sign of active inflammation. Adalimumab concentrations were measured using the homogeneous mobility shift assay. Ninety-one CRP levels and 72 colonoscopies from 98 IBD patients [CD: n = 72 (73%)] were evaluated. Based on receiver operating characteristic analyses, we identified an adalimumab concentration threshold of 11.8,...Continue Reading

References

Mar 5, 2013·Journal of Pharmaceutical and Biomedical Analysis·Shui-Long WangSharat Singh
Jul 31, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Xavier RoblinStephane Paul
Jun 11, 2014·The American Journal of Gastroenterology·Xavier RoblinS Paul
Aug 26, 2015·The American Journal of Gastroenterology·L Peyrin-BirouletJ-F Colombel
Nov 6, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bella UngarShomron Ben-Horin
Dec 19, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Konstantinos PapamichaelMarc Ferrante
Jan 20, 2016·Journal of Crohn's & Colitis·E ZittanM S Silverberg
Feb 14, 2016·Journal of Crohn's & Colitis·Konstantinos Papamichael, Adam S Cheifetz
Feb 19, 2016·Scandinavian Journal of Gastroenterology·Yukihiro MoritaAkira Andoh
Apr 5, 2016·Journal of Gastroenterology and Hepatology·Yukihiro MoritaAkira Andoh
Jul 13, 2016·Journal of Crohn's & Colitis·Konstantinos PapamichaelMarc Ferrante
Feb 22, 2017·The American Journal of Gastroenterology·Konstantinos Papamichael, Adam S Cheifetz
Apr 4, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Konstantinos PapamichaelAdam S Cheifetz
Nov 7, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kenji WatanabeUNKNOWN DIAMOND study group
Apr 13, 2018·Alimentary Pharmacology & Therapeutics·K Papamichael, A S Cheifetz

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Citations

Mar 16, 2019·Expert Review of Clinical Immunology·Jun KatoSakiko Hiraoka
Jul 16, 2019·Expert Review of Clinical Pharmacology·Anne S StrikMark Löwenberg
Dec 7, 2019·The American Journal of Gastroenterology·Thomas ChateauLaurent Peyrin-Biroulet
Apr 12, 2019·Current Opinion in Gastroenterology·Konstantinos Papamichael, Adam S Cheifetz
May 16, 2020·Current Opinion in Rheumatology·Konstantinos Papamichael, Adam S Cheifetz
Mar 7, 2020·Journal of Pediatric Gastroenterology and Nutrition·Isabel Pinto PaisJorge Amil Dias
Jun 28, 2020·International Journal of Colorectal Disease·Mitchell R K L LieC Janneke van der Woude
Aug 9, 2020·Expert Review of Gastroenterology & Hepatology·Arianna Dal BuonoSilvio Danese
May 31, 2019·Scandinavian Journal of Gastroenterology·Neeraj NarulaJohn K Marshall
Jun 3, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rajan N PatelJimmy K Limdi
Jun 11, 2019·Expert Review of Clinical Immunology·Konstantinos PapamichaelAdam S Cheifetz
Sep 4, 2020·Nature Reviews. Gastroenterology & Hepatology·Marjorie ArgolloGeert D'Haens
Jan 27, 2019·Current Treatment Options in Gastroenterology·Christopher MaNiels Vande Casteele
Jul 14, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Pavine L C LefevreNiels Vande Casteele
Jun 10, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Arne CarlsenTore Grimstad
Dec 16, 2020·Revista de gastroenterología de México·J K Yamamoto-FurushoUNKNOWN Grupo del Segundo Consenso Mexicano de Terapia Biológica y Moléculas Pequeñas
Apr 6, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert Battat, William J Sandborn
Jul 29, 2020·Current Drug Targets·Arianna Dal BuonoSilvio Danese
Oct 7, 2021·Clinical and Translational Gastroenterology·Eran ZittanMark S Silverberg
Jan 18, 2022·Expert Review of Clinical Pharmacology·Wannee KantasiripitakErwin Dreesen

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