Maintenance and inheritance of yeast prions

Trends in Genetics : TIG
M F Tuite, S Lindquist

Abstract

The unusual genetic behaviour of two yeast extrachromosomal elements [PSI] and [URE3] is entirely consistent with a prion-like mechanism of inheritance involving an autocatalytic alteration in the conformation of a normal cellular protein. In the case of both yeast determinants the identity of the underlying cellular prion protein is known. The discovery that the molecular chaperone Hsp104 is essential for the establishment and maintenance of the [PSI] determinant provides an explanation for several aspects of the puzzling genetic behaviour of these determinants. What remains to be explained is whether these determinants represent 'disease states' of yeast or represent the first examples of a unique mechanism for producing a heritable change in phenotype without an underlying change in genotype.

References

Jun 14, 1991·Science·S B Prusiner
Jun 1, 1990·Science·Y Sanchez, S L Lindquist
Jun 15, 1988·Gene·V V KushnirovS G Inge-Vechtomov
Feb 20, 1988·Journal of Molecular Biology·P G Wilson, M R Culbertson
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·Y YoshinakaS Oroszlan
Dec 6, 1974·Biochimica Et Biophysica Acta·H HofstetterC Weissmann
May 1, 1971·Journal of Bacteriology·F Lacroute
Nov 15, 1995·Circulation·R SheldonM L Koshman
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·J TatzeltW J Welch
Jun 22, 1995·Nature·C Weissmann
Jan 1, 1994·Annual Review of Microbiology·S B Prusiner
Apr 1, 1995·Molecular and Cellular Biology·S XuM C Brandriss
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M PanF E Cohen
Aug 11, 1994·Nature·D A KociskoB Caughey
Dec 1, 1994·Nature·D A ParsellS Lindquist
Jul 2, 1993·Cell·H BüelerC Weissmann
Jan 1, 1994·Trends in Cell Biology·C Weissmann
Jan 1, 1975·Molecular & General Genetics : MGG·M Aigle, F Lacroute
Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A SinghF Sherman

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Citations

Aug 27, 1998·Molecular Biotechnology·N Hunter
Jul 1, 1997·Trends in Genetics : TIG·R Gabizon, A Taraboulos
Aug 1, 1997·Trends in Genetics : TIG·J B HollickV L Chandler
Apr 28, 1999·Trends in Genetics : TIG·P Silar, M J Daboussi
May 1, 1998·Trends in Ecology & Evolution·E JablonkaE Avital
Oct 6, 1999·Current Opinion in Neurobiology·J P Brockes
Sep 26, 2013·Nature Reviews. Molecular Cell Biology·Shannon M DoyleSue Wickner
Feb 20, 1999·The Biochemical Journal·E Fernandez-BellotC Cullin
Feb 26, 2000·Molecular Microbiology·Y O ChernoffS M Belenkiy
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·I L DerkatchS W Liebman
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·S S EaglestoneM F Tuite
Oct 1, 2004·Molecular and Cellular Biology·Magdalena Rakwalska, Sabine Rospert
Nov 8, 2008·Molekuliarnaia biologiia·L N MironovaM D Ter-Avanesian
Jan 1, 1997·Annual Review of Genetics·S B Prusiner, M R Scott
Aug 15, 2000·Journal of Structural Biology·D G Lynn, S C Meredith
Aug 24, 2013·The Journal of Biological Chemistry·Stanislav A BondarevGalina A Zhouravleva
Jan 9, 1999·The Journal of Biological Chemistry·S W Liebman, I L Derkatch
May 26, 2020·The EMBO Journal·Jessica TittelmeierCarmen Nussbaum-Krammer
Jan 16, 1999·Molecular and Cellular Biology·G P NewnamY O Chernoff
Jan 1, 2014·Frontiers in Molecular Biosciences·Rui Sousa
Dec 12, 2003·The Journal of Biological Chemistry·Valerie GrimmingerStefan Walter
Jul 22, 2018·Journal of Molecular Biology·Anupam K Chakravarty, Daniel F Jarosz
Jun 1, 1997·Molecular and Cellular Biology·X Le GoffO Jean-Jean
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·J E McCarthy
Dec 10, 1999·Microbiology and Molecular Biology Reviews : MMBR·R B WicknerB T Roberts
Apr 4, 2000·Genetics·J B HollickV L Chandler
Feb 25, 2009·Biochimica Et Biophysica Acta·Sharmistha Kundu, Craig L Peterson
Nov 23, 2021·Journal of Molecular Biology·Aishwarya Agarwal, Samrat Mukhopadhyay

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