Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory

Schizophrenia Research
Junghoon KimTyrone D Cannon

Abstract

Impairments in working memory (WM) have been proposed to underlie various cognitive and functional impairments in schizophrenia. However, the nature and extent of the dysfunction remain unclear. The present study attempted to examine the integrity of sub-components of working memory in schizophrenia within the framework of the multiple-component working memory model proposed by Baddeley. Two sets of visuospatial and verbal delayed-response tasks were developed which had comparable formats and difficulties across domains. In Experiment 1, demands on the central executive (CE) were manipulated by requiring subjects either (1) to simultaneously maintain and transform information (maintenance-and-manipulation condition) or (2) just to maintain this information (maintenance-only condition). In Experiment 2, the amount of information to be maintained over the delay was parametrically varied to evaluate demands on the temporary maintenance component of working memory. Patients (N=16) performed worse than controls (N=16) in both conditions of Experiment 1; however, simultaneous maintenance and manipulation was associated with a significantly greater performance reduction in the patients. In Experiment 2, both patients (N=15) and contro...Continue Reading

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Related Concepts

Overinclusion
Memory
Memory Loss
Memory for Designs Test
Pattern Recognition, Visual
Psychomotor Performance
Reaction Time
Schizophrenia
Schizophrenic Psychology
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