PMID: 11605781Oct 19, 2001Paper

Maintenance intravenous iron therapy in pediatric hemodialysis patients

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Henry E G MorganDenis F Geary

Abstract

Iron supplementation is required for optimal response to erythropoietin (EPO) in hemodialysis patients. This is due to blood lost in the dialysis tubing after dialysis and the increased demand for iron by EPO therapy. Maintenance intravenous (IV) iron was administered according to a standardized protocol to pediatric patients on hemodialysis in our institution. The effect of this protocol on EPO dose, iron indices, anemia, and medication costs was evaluated. Data on two groups of patients were retrieved from the health records. Group 1 (n=14) consisted of patients treated in the 18 months prior to the protocol. These patients received oral iron supplements and occasional IV iron. Group 2 (n=5) consisted of all patients treated with the IV iron protocol. There was no difference in clinical characteristics and mean values for monthly hemoglobin, serum iron, ferritin, and transferrin saturation between groups. The dose of EPO was significantly reduced in group 2 compared with group 1 (193.9 +/- 121.4 vs. 73.9 +/- 39.0 units/kg per week, P<0.05). Medication costs were reduced by 26% in group 2. No significant adverse events were seen. Maintenance IV iron reduced the dose of EPO required to maintain blood hemoglobin levels. Our resu...Continue Reading

Citations

Jun 23, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bradley A WaradyUNKNOWN Ferrlecit Pediatric Study Group
Mar 8, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Bradley A WaradyUNKNOWN Ferrlecit Pediatric Study Group
Jan 25, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Susan M Koshy, Denis F Geary
Jan 9, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Walter H Hörl
Dec 17, 2003·Kidney International·Blanche M ChaversWendy L St Peter
Jul 31, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Alan S KligerLynda Szczech
Dec 19, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stuart L GoldsteinBradley A Warady
Oct 4, 2005·Advances in Chronic Kidney Disease·Larry A Greenbaum
Jul 27, 2005·Therapeutic Drug Monitoring·David Michael WoodPaul Ivor Dargan
Sep 7, 2011·Nature Reviews. Nephrology·Meredith A Atkinson, Susan L Furth

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