PMID: 8589464Oct 1, 1995Paper

Maintenance of adequate hemodialysis access. Prevention of neointimal hyperplasia

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
T E TaberT L Roberts

Abstract

The maintenance of adequate hemodialysis vascular access is frequently complicated in the patient with polytetrafluoroethylene (PTFE) A-V hemodialysis grafts by venous anastomotic stenosis. This stenosis is caused by neointimal hyperplasia (NIH), a response to vascular injury. In this study, the authors prospectively analyzed the effect of a short-term regimen consisting of administration of two medications, heparin and low molecular weight dextran, on the development of NIH at the venous anastomosis in 79 patients with PTFE A-V hemodialysis grafts. In addition, they evaluated other parameters' effects on the development of NIH. In comparison with control subjects, heparin had some effect in minimizing the development of NIH in the PTFE grafts when evaluated radiologically at 3 months, although this effect was not statistically significant. Low molecular weight dextran, however, had no trend or statistically significant effect on this venous anastomotic narrowing. Interestingly, patient age, use of calcium channel blockers, and presence of diabetes mellitus (DM) all appeared to affect the development of NIH. Increasing age and use of calcium channel blockers was associated with decreased development of NIH; conversely, DM was a...Continue Reading

Citations

Sep 7, 2011·Nature Reviews. Nephrology·Dominik Müller, Stuart L Goldstein
Feb 9, 2012·Nature Reviews. Nephrology·Seung-Hyeok Han, Dae-Suk Han
Aug 23, 2002·Seminars in Dialysis·A J Freemont
Mar 11, 2004·Seminars in Vascular Surgery·Christopher J AbularrageSubodh Arora
Feb 28, 2007·Journal of Biomaterials Science. Polymer Edition·Suk Ho BhangByung-Soo Kim
Sep 17, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R EzzahiriJ H Tordoir
Jul 18, 2015·The Cochrane Database of Systematic Reviews·Nicola C Tanner, Anthony Da Silva

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