Maintenance of allogeneic cell recognition in allograft tolerant mice

Immunology Letters
V ViklickýM Hasek

Abstract

The organ distribution of 51Cr-labelled lymph node cells following transfer to syngeneic, allogeneic and specifically tolerant allogeneic recipients were compared. Neonatal induction of transplantation tolerance in several donor-recipient combinations involving different H-2 haplotypes had no effect on the reduction of homing into lymph nodes and the values of the homing did not differ from those of the untreated allogeneic recipients. In both cases, they amounted to 45-55% of the syngeneic controls. Even those neonatally treated animals, which had not been rendered tolerant at birth and rejected test skin grafts, were not capable of removing the transferred allogeneic cells by a typical immune elimination. The results indicate that animals recognize allogeneic cells, irrespective of whether or not they reject test skin grafts.

References

Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L W LawT Fischetti

❮ Previous
Next ❯

Citations

Jun 1, 1987·Immunology and Cell Biology·P McCullagh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.