Maintenance of cell type-specific connectivity and circuit function requires Tao kinase

Nature Communications
Federico M TenediniPeter Soba

Abstract

Sensory circuits are typically established during early development, yet how circuit specificity and function are maintained during organismal growth has not been elucidated. To gain insight we quantitatively investigated synaptic growth and connectivity in the Drosophila nociceptive network during larval development. We show that connectivity between primary nociceptors and their downstream neurons scales with animal size. We further identified the conserved Ste20-like kinase Tao as a negative regulator of synaptic growth required for maintenance of circuit specificity and connectivity. Loss of Tao kinase resulted in exuberant postsynaptic specializations and aberrant connectivity during larval growth. Using functional imaging and behavioral analysis we show that loss of Tao-induced ectopic synapses with inappropriate partner neurons are functional and alter behavioral responses in a connection-specific manner. Our data show that fine-tuning of synaptic growth by Tao kinase is required for maintaining specificity and behavioral output of the neuronal network during animal growth.

References

Jun 1, 1993·Journal of Neurobiology·H KeshishianM E Halpern
Apr 23, 2003·Cell·W Daniel TraceySeymour Benzer
Feb 12, 2005·Science·K L BriggmanW B Kristan
Sep 2, 2005·Nature Neuroscience·Tobias M RasseStephan J Sigrist
Dec 13, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vikas KumarGang-Yi Wu
Dec 7, 2007·Current Biology : CB·Richard Y HwangW Daniel Tracey
Jan 23, 2009·Developmental Neurobiology·Florian LeissGaia Tavosanis
Oct 2, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory Z Tau, Bradley S Peterson
Jul 22, 2010·Journal of Cell Science·Tao LiuBuzz Baum
Nov 27, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Adam Bleckert, Rachel O L Wong
May 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chun HanYuh-Nung Jan
Nov 12, 1986·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J G WhiteS Brenner
Jun 12, 2012·Nature Neuroscience·Froylan Calderon de AndaLi-Huei Tsai
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maarten F ZwartMatthias Landgraf
Jan 23, 2014·Neurocirugía·Javier Abarca-OlivasPedro Moreno-López
Feb 11, 2014·Nature Methods·Nathan C KlapoetkeEdward S Boyden
Apr 22, 2014·Current Biology : CB·Limin YangBing Ye
Aug 26, 2014·Annual Review of Cell and Developmental Biology·Shaul Yogev, Kang Shen
Nov 14, 2014·ELife·Till F M AndlauerStephan J Sigrist
Feb 24, 2015·Current Biology : CB·Louise CoutonMatthias Landgraf
Oct 6, 2015·Annual Review of Cell and Developmental Biology·Martin M Riccomagno, Alex L Kolodkin
Nov 26, 2015·Current Biology : CB·Alison J Barker, Herwig Baier

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Citations

Apr 9, 2021·Nature·Sarah D AckermanChris Q Doe
Apr 20, 2021·Frontiers in Molecular Neuroscience·Chun HuLin Xiao

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Methods Mentioned

BETA
electron microscopy
light microscopy
transgenic
dissection
confocal microscopy
PCR

Software Mentioned

ImageJ
AutoQuant
Fiji
MATLAB
FrameGrabber
Syb
Prism
Imaris
GRASP

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