Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments.

Arthritis Research & Therapy
Jean-Luc DavignonAlain Cantagrel

Abstract

Anti-tumor necrosis factor (TNF)-α biotherapies have considerably changed the treatment of rheumatoid arthritis (RA). However, serious infections are a major concern in patients with rheumatic diseases treated with anti-TNF-α. Little is known about viral, especially latent, infections in anti-TNF-α treatments. Infections by cytomegalovirus (CMV), a β-herpes virus, are frequent and induce a strong CD4pos T-cell immunity, which participates in the control of infection. We thus have chosen to analyze the CD4pos T-cell response to CMV antigens as a model of antiviral response in RA patients treated with anti-TNF-α. CD28 expression was evaluated. We have measured the CD4pos response to CMV antigens in RA patients, before and after initiation of treatment with an anti-TNF-α agent. The intracellular production of interferon (IFN)-γ in total and CD28neg CD4pos T cells in response to CMV antigens (Ags) was evaluated with flow cytometry. The proliferation of total CD4pos T cells in the presence of CMV antigens was measured with 3H-thymidine incorporation. Anti-TNF-α treatments impaired neither the anti-CD4pos anti-CMV IFN-γ response nor the proliferative response in patients. The percentage of CD28neg CD4pos cells remained constant. Our ...Continue Reading

References

Nov 15, 1991·European Journal of Biochemistry·G CamussiF Bussolino
May 1, 1996·The Journal of Clinical Investigation·D SchmidtC M Weyand
Oct 13, 2001·The New England Journal of Medicine·J KeaneM M Braun
Dec 7, 2002·European Journal of Gastroenterology & Hepatology·Daniel HelblingMartin Krause
Dec 28, 2002·Springer Seminars in Immunopathology·J G P SissonsM R Wills
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Sep 17, 2003·The Journal of Experimental Medicine·Elisabeth AmyesMargaret F C Callan
Feb 22, 2005·Current Pharmaceutical Design·Eric M Ruderman
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mari Mizuta, Mindy G Schuster
Sep 9, 2005·The Journal of Experimental Medicine·Andrew W SylwesterLouis J Picker
Jul 25, 2006·Arthritis Research & Therapy·Haïfa HamdiUNKNOWN RATIO (Recherche sur Anti-TNF et Infections Opportunistes) Study Group
Aug 17, 2006·Journal of Gastroenterology and Hepatology·Debbie M NathanPeter R Gibson
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marielle ThewissenPiet Stinissen
Feb 20, 2009·JAMA : the Journal of the American Medical Association·Anja StrangfeldAngela Zink

❮ Previous
Next ❯

Citations

Jul 6, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jeffrey D McCurdyDavid H Bruining
Feb 28, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Giovanni AlmanzarMartina Prelog
Nov 27, 2015·Seminars in Arthritis and Rheumatism·Fabrizio CantiniUNKNOWN Italian board for the TAilored BIOlogic therapy (ITABIO)
Apr 10, 2013·Alimentary Pharmacology & Therapeutics·W FriesA Cascio
Jul 17, 2012·Digestive Diseases·Anna Kohn, Patrizia Meddi
Oct 14, 2018·Arthritis Research & Therapy·Jean-Luc DavignonAlain Cantagrel
Jan 9, 2021·Arthritis Research & Therapy·Jean-Luc DavignonAlain Cantagrel

❮ Previous
Next ❯

Methods Mentioned

BETA
flow-cytometry
flow cytometry

Software Mentioned

Stata

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.